A Bibliometric Analysis of the Literature on Irisin from 2012–2021

Abstract

Irisin is a hormone-like molecule mainly released by skeletal muscles in response to exercise, which is proposed to induce the ‘browning’ of white adipose tissue. Since its identification, irisin was reported to be closely associated with many metabolic diseases, including type 2 diabetes mellitus (T2DM), obesity, cardiovascular disease (CVD), and metabolic bone diseases. In recent years, irisin has attracted increasing research interest, and numerous studies have been published in this field. Thus, it is essential to identify the current research status of irisin and measure research hotspots and possible future trends. In this study, by utilizing two visualization software named CiteSpace and VOSviewer, we analyzed 1510 Web of Science publications on irisin published from 2012 to 2021. Our results show that the number of irisin-related articles published annually has increased significantly. China participates in the most studies, followed by the United States and Turkey. Firat University, Harvard University, and Shandong University are three major institutions with larger numbers of publications. The analysis of keywords co-occurrence indicates that insulin resistance, inflammation, and circulating irisin levels in serum are the research hotspots. Apoptosis, BDNF, and osteoporosis will likely become the focus of future research related to irisin. Overall, this study may provide helpful insights for researchers to understand the current research situation and identify the potential frontiers of irisin.

Irisin inhibits NLRP3 inflammasome activation in HG/HF incubated cardiac microvascular endothelial cells with H/R injury

“…Irisin has been shown to induce anti‐apoptotic actions in various diseases. Previous studies have shown that irisin could inhibit apoptosis including cardiomyocyte apoptosis, endothelial cell apoptosis and pancreatic β cell apoptosis by the Akt, ERK, p38 MAPK, and TLR/MyD88 signaling pathway 31 . Irisin could also protect nucleus pulposus cells against senescence and apoptosis by activating autophagy 32 .…”

“…Furthermore, NLRP3 inflammasome activation is also responsible for vascular endothelial dysfunction in diabetes. 31 Irisin could also protect nucleus pulposus cells against senescence and apoptosis by activating autophagy. 32 And our previous study has also shown that irisin can activate the Akt/eNOS pathway which considered as a survival pathway, and Akt/eNOS pathway may play an important role in the anti-apoptosis effects of irisin.…”

The Modulation of Adipokines, Adipomyokines, and Sleep Disorders on Carcinogenesis

“…Irisin is the best-recognized myokine [ 87 ]; it is secreted by myocytes and adipocytes, and is also referred to as an adipomyokine [ 88 ]. Its levels depend on muscle mass and physical activity levels [ 89 ].…”

Researches on Stem and Progenitor Cells in Intervertebral Discs: An Analysis of the Scientific Landscape

“…Bibliometric analysis and visualization are not only more effective methods to assess the thematic development of structural contents. More importantly, it can help researchers to better understand comprehensively about hotspots, frontiers, and trends in particular topic [5][6][7]. Science Citation Index Expanded (SCI-E) of Web of Science (WOS) Core Collection Database is widely used as an important tool for scientific statistics and scientific evaluation [8].…”