A Bicyclic Diterpenoid with a New 15,16-Dinorlabdane Carbon Skeleton from Leonurus japonicus and Its Coagulant Bioactivity

Fu, Peng; Xiong, Liang; Zhao, Xiaomei

doi:10.3390/molecules181113904

Cited by 21 publications

(5 citation statements)

References 16 publications

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“…LEO is a specific alkaloid only found in Leonurus japonicus Houtt. Modern pharmacological studies have shown that it has a variety of biological activities such as vasodilation [ 12 ], antiplatelet aggregation and inhibition of vasoconstriction [ 13 – 16 ], anticoagulant [ 17 ], anti-inflammatory [ 18 ], antioxidative [ 19 ], anti-ischemia, antiapoptosis [ 20 , 21 ], and heart protection [ 22 ]. However, whether it can repair vascular endothelial cell injury and promote angiogenesis through antioxidant stress has not been clarified.…”

Section: Introductionmentioning

confidence: 99%

Leonurine Ameliorates Oxidative Stress and Insufficient Angiogenesis by Regulating the PI3K/Akt‐eNOS Signaling Pathway in H₂O₂‐Induced HUVECs

Liao

Gong

Zhou

et al. 2021

Oxidative Medicine and Cellular Longevity

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Thrombus is considered to be the pathological source of morbidity and mortality of cardiovascular disease and thrombotic complications, while oxidative stress is regarded as an important factor in vascular endothelial injury and thrombus formation. Therefore, antioxidative stress and maintaining the normal function of vascular endothelial cells are greatly significant in regulating vascular tension and maintaining a nonthrombotic environment. Leonurine (LEO) is a unique alkaloid isolated from Leonurus japonicus Houtt (a traditional Chinese medicine (TCM)), which has shown a good effect on promoting blood circulation and removing blood stasis. In this study, we explored the protective effect and action mechanism of LEO on human umbilical vein endothelial cells (HUVECs) after damage by hydrogen peroxide (H2O2). The protective effects of LEO on H2O2-induced HUVECs were determined by measuring the cell viability, cell migration, tube formation, and oxidative biomarkers. The underlying mechanism of antioxidation of LEO was investigated by RT-qPCR and western blotting. Our results showed that LEO treatment promoted cell viability; remarkably downregulated the intracellular generation of reactive oxygen species (ROS), malondialdehyde (MDA) production, and lactate dehydrogenase (LDH); and upregulated the nitric oxide (NO) and superoxide dismutase (SOD) activity in H2O2-induced HUVECs. At the same time, LEO treatment significantly promoted the phosphorylation level of angiogenic protein PI3K, Akt, and eNOS and the expression level of survival factor Bcl2 and decreased the expression level of death factor Bax and caspase3. In conclusion, our findings suggested that LEO can ameliorate the oxidative stress damage and insufficient angiogenesis of HUVECs induced by H2O2 through activating the PI3K/Akt-eNOS signaling pathway.

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Section: Introductionmentioning

confidence: 99%

Leonurine Ameliorates Oxidative Stress and Insufficient Angiogenesis by Regulating the PI3K/Akt‐eNOS Signaling Pathway in H₂O₂‐Induced HUVECs

Liao

Gong

Zhou

et al. 2021

Oxidative Medicine and Cellular Longevity

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“…It has traditionally used to treat gynecological and obstetrical diseases, as indicated by its name, and is beneficial to women [69]. More than 280 secondary metabolites have been isolated from this plant, showing various activities, such as anticoagulant [70], antibacterial [71,72], antiplatelet aggregation [73][74][75], vasodilation [76], angiogenesis [77], and effects on uterine smooth muscle [78].…”

Section: Research Plants: Utilization and Significancementioning

confidence: 99%

Nectar Characteristics and Honey Production Potential of Five Rapeseed Cultivars and Two Wildflower Species in South Korea

Na,

Kim,

Park

2024

Plants

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The growing beekeeping industry in South Korea has led to the establishment of new honey plant complexes. However, studies on honey production from each species are limited. This study aimed to assess the honey production potential of various Brassica napus cultivars and two wildflower species. The nectar characteristics of B. napus varied significantly among the cultivars. Absolute sugar concentrations differed among the cultivars, but sugar composition ratios were similar. In contrast, the amino acid content remained relatively uniform regarding percentage values, irrespective of the absolute concentrations. Estimations of honey potential production per hectare (kg/ha) resulted in the following ranking among cultivars: ‘JM7003’ (107.1) > ‘YS’ (73.0) > ‘JM7001’ (63.7) > ‘TL’ (52.7) > ‘TM’ (42.4). The nectar volume of Pseudolysimachion rotundum var. subintegrum and Leonurus japonicus increased during the flowering stage. P. rotundum var. subintegrum was sucrose-rich and L. japonicus was sucrose-dominant. Both species predominantly contained phenylalanine, P. rotundum var. subintegrum had glutamine as the second most abundant amino acid, and L. japonicus had tyrosine. The honey production potential was 152.4 kg/ha for P. rotundum var. subintegrum and 151.3 kg/ha for L. japonicus. These findings provide a basis for identifying food resources for pollinators and selecting plant species to establish honey plant complexes.

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“…The dried herb is used in Traditional Chinese Medicine for the treatment of various diseases, especially menstrual disturbances, dysmenorrhea, and amenorrhea [1]. Recently, phytochemical studies on this plant have been reported [2,3,4,5,6,7,8,9,10]. Our previous investigation on two plants of the family of Lamiaceae resulted in the isolation of a number of new labdane diterpenes [11,12].…”

Section: Introductionmentioning

confidence: 99%

Isoleojaponin, a New Halimane Diterpene Isolated from Leonurus japonicus

Wang

et al. 2015

Molecules

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Leojaponin (2), a labdane diterpene, was isolated from the EtOH extract of the herb of Leonurus japonicus together with a new halimane diterpene named isoleojaponin (1). Isoleojaponin has a new diterpene skeleton with a unique cross-conjugated α,β-unsaturated ketone system, Their structures were elucidated by physical and spectroscopic analysis, and the relative configuration of the chiral C-9 carbon was determined by a computational method, and analysis of its possible biogenesis pathways.

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A Bicyclic Diterpenoid with a New 15,16-Dinorlabdane Carbon Skeleton from Leonurus japonicus and Its Coagulant Bioactivity

Cited by 21 publications

References 16 publications

Leonurine Ameliorates Oxidative Stress and Insufficient Angiogenesis by Regulating the PI3K/Akt‐eNOS Signaling Pathway in H₂O₂‐Induced HUVECs

Leonurine Ameliorates Oxidative Stress and Insufficient Angiogenesis by Regulating the PI3K/Akt‐eNOS Signaling Pathway in H₂O₂‐Induced HUVECs

Nectar Characteristics and Honey Production Potential of Five Rapeseed Cultivars and Two Wildflower Species in South Korea

Isoleojaponin, a New Halimane Diterpene Isolated from Leonurus japonicus

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A Bicyclic Diterpenoid with a New 15,16-Dinorlabdane Carbon Skeleton from Leonurus japonicus and Its Coagulant Bioactivity

Cited by 21 publications

References 16 publications

Leonurine Ameliorates Oxidative Stress and Insufficient Angiogenesis by Regulating the PI3K/Akt‐eNOS Signaling Pathway in H2O2‐Induced HUVECs

Leonurine Ameliorates Oxidative Stress and Insufficient Angiogenesis by Regulating the PI3K/Akt‐eNOS Signaling Pathway in H2O2‐Induced HUVECs

Nectar Characteristics and Honey Production Potential of Five Rapeseed Cultivars and Two Wildflower Species in South Korea

Isoleojaponin, a New Halimane Diterpene Isolated from Leonurus japonicus

Contact Info

Product

Resources

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Leonurine Ameliorates Oxidative Stress and Insufficient Angiogenesis by Regulating the PI3K/Akt‐eNOS Signaling Pathway in H₂O₂‐Induced HUVECs

Leonurine Ameliorates Oxidative Stress and Insufficient Angiogenesis by Regulating the PI3K/Akt‐eNOS Signaling Pathway in H₂O₂‐Induced HUVECs