2023
DOI: 10.3389/fneur.2023.1277996
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A bidirectional Mendelian randomization study investigating the causal role between gut microbiota and insomnia

Jie Yang,
Tengfei Su,
Yating Zhang
et al.

Abstract: BackgroundIt has emerged that disturbances of the gut microbiota (GM) are linked to insomnia. However, the causality of the observed associations remains uncertain.MethodsWe conducted a two-sample Mendelian randomization analysis based on genome-wide association study data to explore the possible causal link between GM and insomnia. The GM data were from the MiBioGen consortium, while the summary statistics of insomnia were obtained from the FinnGen consortium R9 release data. Cochran’s Q statistics were used … Show more

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