A bidirectional relationship between anxiety, depression and gastrointestinal symptoms in Parkinson’s disease

Jones, Jacob D.; Dominguez, Brandon; Bunch, Joseph; Uribe, Carmen; Valenzuela, Yenny; Jacobs, Jonathan P.

doi:10.1016/j.prdoa.2021.100104

Cited by 13 publications

(13 citation statements)

References 36 publications

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“…Anxiety disorders are the foremost prevalent psychiatric disorders among the general population [ 23 ]. Ample scientific reports indicated that the clinical characteristics of anxiety and GI dysfunctions coexist to a more significant extent [ 24 , 25 ]. To note, the pestilent symptoms of both anxiety and GI disorders have been mutually known to predispose and exacerbate the pathogenic signatures between them but the definitely combined etiology of these diseases remains obscure due to their co-morbid nature [ 24 , 26 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

Omeprazole treatment manifests anxiolytic effects in a cysteamine hydrochloride induced mouse model of gastrointestinal disorder

Rethinavel¹,

Selvaraj²,

Balakrishnan³

et al. 2022

Heliyon

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Section: Discussionmentioning

confidence: 99%

Omeprazole treatment manifests anxiolytic effects in a cysteamine hydrochloride induced mouse model of gastrointestinal disorder

Rethinavel¹,

Selvaraj²,

Balakrishnan³

et al. 2022

Heliyon

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“…Data from 10 national or international sites from were utilized in the current sample (see https://www.ppmi-info.org/about-ppmi/ppmi-clinical-sites for a complete list of sites). The sample has 100% (Jones, Dominguez, et al, 2021; Jones, Timblin, et al, 2021; Jones, Uribe, et al, 2021), 88% (Jones, Burroughs, et al, 2020; Jones, Rahmani, et al, 2020), and 64% (Jones et al, 2019) overlap with our past work. For additional details, please see Marek et al (2011) and https://www.ppmi-info.org/.…”

Section: Methodsmentioning

confidence: 98%

Physical inactivity links depressive symptoms and cognitive functioning among individuals with Parkinson’s disease.

Timblin¹,

Rahmani²,

Ryczek³

et al. 2022

Neuropsychology

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Objective: Parkinson’s disease (PD) is a neurodegenerative disorder caused by disruption of dopamine-producing cells. PD is associated with motor symptoms and nonmotor symptoms including depression and cognitive impairment. Past research suggests an association between depression and cognitive impairment in PD. Physical activity may have a therapeutic effect on both depression and cognitive impairment. The present study investigates if physical activity mediates the association between depressive symptoms and cognition in a longitudinal sample of individuals with PD. Method: Participants include individuals newly diagnosed with PD (N = 487) enrolled in the Parkinson’s Progression Marker Initiative (PPMI). Participants completed an array of neuropsychological tests over the course of 5 years, as well as questionnaires of depression and physical activity. Between-person and within-person effects of depression and cognition mediated through physical activity were analyzed using structural equation modeling. Results: A significant direct effect demonstrated depression was associated with worse global cognitive functioning. Furthermore, there was a significant indirect within-person effect, indicating that physical activity fully mediated the association between depression and cognition. Individuals who became more depressed over time became less physically active and subsequently experienced cognitive decline over the 5-year period. Conclusions: Findings have implications for prognostic detection and/or the role of physical activity interventions to buffer effects of depression on cognitive impairment among individuals diagnosed with PD. Physical interventions may potentially be implemented among depressed persons to preserve cognitive functioning. Worsened depression early during PD may be a risk factor for inactivity and cognitive diminishment.

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“…Gut microbiotic changes that play a crucial role in the bidirectional communication between the gut and the brain (Klann et al 2022 ) with a close link between multiple movement disorders and gastrointestinal dysfunction (Talman and Pfeiffer 2022 ), suggest that the gut microbes may shape neuronal development, modulate neurotransmission and affect behavior, have been associated with the pathomechanism of DPD (Dogra et al 2022 ; Mendonça et al 2020 ; Moustafa et al 2021 ; Socala et al 2021 ) (Felice et al 2016 ; Jones et al 2021 ; Tan et al 2022 ; Xie et al 2022 ). There is increasing evidence for the highly complex relationship between the gut and the brain in PD, including the potential role of the vagus nerve, αSyn deposition in the enteric nervous system, related to intestinal permeability, autonomic dysfunction, inflammation, neural immune system and the gut microbiome (Nowak et al 2022 ; Tan et al 2022 ; Tansey et al 2022 ; Warnecke et al 2022 ).…”

Section: The Gut-brain Axismentioning

confidence: 99%

The pathobiological basis of depression in Parkinson disease: challenges and outlooks

Ka¹

2022

J Neural Transm

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Depression, with an estimated prevalence of about 40% is a most common neuropsychiatric disorder in Parkinson disease (PD), with a negative impact on quality of life, cognitive impairment and functional disability, yet the underlying neurobiology is poorly understood. Depression in PD (DPD), one of its most common non-motor symptoms, can precede the onset of motor symptoms but can occur at any stage of the disease. Although its diagnosis is based on standard criteria, due to overlap with other symptoms related to PD or to side effects of treatment, depression is frequently underdiagnosed and undertreated. DPD has been related to a variety of pathogenic mechanisms associated with the underlying neurodegenerative process, in particular dysfunction of neurotransmitter systems (dopaminergic, serotonergic and noradrenergic), as well as to disturbances of cortico-limbic, striato-thalamic-prefrontal, mediotemporal-limbic networks, with disruption in the topological organization of functional mood-related, motor and other essential brain network connections due to alterations in the blood–oxygen-level-dependent (BOLD) fluctuations in multiple brain areas. Other hypothetic mechanisms involve neuroinflammation, neuroimmune dysregulation, stress hormones, neurotrophic, toxic or metabolic factors. The pathophysiology and pathogenesis of DPD are multifactorial and complex, and its interactions with genetic factors, age-related changes, cognitive disposition and other co-morbidities awaits further elucidation.

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A bidirectional relationship between anxiety, depression and gastrointestinal symptoms in Parkinson’s disease

Abstract: Highlights Gastrointestinal (GI) and mood symptoms are common in Parkinson’s disease. Depression and anxiety are bidirectional risk factors for GI distress. Association between GI and mood symptoms may reflect disrupted Gut-Brain axis.

Cited by 13 publications

References 36 publications

Omeprazole treatment manifests anxiolytic effects in a cysteamine hydrochloride induced mouse model of gastrointestinal disorder

Omeprazole treatment manifests anxiolytic effects in a cysteamine hydrochloride induced mouse model of gastrointestinal disorder

Physical inactivity links depressive symptoms and cognitive functioning among individuals with Parkinson’s disease.

The pathobiological basis of depression in Parkinson disease: challenges and outlooks

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