A Bifunctional Photosensitizer for Enhanced Fractional Photodynamic Therapy: Singlet Oxygen Generation in the Presence and Absence of Light

Turan, Ilke Simsek; Yıldız, Deniz; Türksoy, Abdurrahman; Günaydın, Gürcan; Akkaya, Engin U.

doi:10.1002/ange.201511345

Cited by 51 publications

(12 citation statements)

References 57 publications

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“…Nanocomposite is usually fabricated by integrating two or more types of functional nanomaterials in one nanoplatform and cooperative effects will be realized. [ 62 ] The approaches to fabricate all‐in‐one nanoplatforms include in situ growth, chemical bond coupling, physical adsorption, layer‐by‐layer assembly, and chelation between organic molecules and MnO 2 . Schematic illustrations of the strategies for construction of MnO 2 ‐based all‐in‐one nanoplatforms and the representative transmission electron microscopy images are shown in Figure .…”

Section: Construction Of Mno2‐based Nanoplatformsmentioning

confidence: 99%

Construction of Smart Manganese Dioxide‐Based All‐in‐One Nanoplatform for Cancer Diagnosis and Therapy

et al. 2020

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Manganese dioxide (MnO 2)-based functional nanomaterials have attracted great attention in the fields of nanoscience, biosensors, bioimaging, drug/ gene delivery, and cancer therapy. Especially, all-in-one tumor microenvironment (TME) responsive MnO 2-based nanoagents have become a research hotspot due to their simple fabrication procedure, high specific surface area, controllable size and morphologies, easy surface modification, TME response, and oxygen generation. This review aims to provide a comprehensive overview of strategies for construction of MnO 2-based all-in-one nanoplatforms for cancer diagnosis and therapy. Major highlighted topics in this paper focus on the controllable fabrication of MnO 2 nanobuilding blocks, tumor targeting accumulation, working mechanisms of enhancing therapeutic efficacy, and the necessary considerations for construction of all-in-one nanoplatform. Finally, the current challenges and future directions in this rapidly growing research field are also discussed, which will provide guidance on the future works about the clinical translation of MnO 2-based all-in-one nanoplatform. 1. Introduction Cancer is one of the life-threatening diseases with high annual mortality rate. Due to the abnormal structure of tumor blood vessels, abnormal proliferation, and special metabolic patterns of tumor cells, the tumor microenvironment (TME) displays obvious abnormal characteristics, such as hypoxia, high H 2 O 2 and glutathione (GSH) concentration, and low pH (4.5-5.0). [1] Despite many efforts have been made to develop new strategies for cancer therapy, heterogeneous tumoral tissue and unique TME limited the therapeutic efficacy. [2] The results obtained from laboratory research and preclinical practice indicate that monotherapy cannot completely eradicate the tumor

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Section: Construction Of Mno2‐based Nanoplatformsmentioning

confidence: 99%

Construction of Smart Manganese Dioxide‐Based All‐in‐One Nanoplatform for Cancer Diagnosis and Therapy

et al. 2020

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“…Recently, specific aromatic organic compounds have been reported to react with singlet oxygen to form the corresponding endoperoxides (EPOs), such as naphthalene, 2pyridones and anthracene derivatives. 2,[23][24][25][26][27][28][29] Many kinds of EPOs are able to convert back to the parent aromatic organic compounds and singlet oxygen under external thermal, photo or chemical stimuli, which allow a clean generation of singlet oxygen without remaining oxidation reagents and sensitizers, and are not restricted to the aqueous media. The reversibility of the reaction allows applications of EPOs in the area of singlet oxygen storage, fluorescent photo-switching and photodynamic therapy.…”

Section: Introductionmentioning

confidence: 99%

Capture and Release of Singlet Oxygen in Coordination-Driven Self-Assembled Organoplatinum(II) Metallacycles

Fudickar

Tang

et al. 2020

J. Am. Chem. Soc.

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Singlet oxygen ( 1 O 2 ), as an important active reagent, has found wide applications in photodynamic therapy (PDT), synthetic chemistry and materials science. Organic conjugated aromatics serving as hosts to capture and release singlet oxygen have been systematically investigated over the last decades. Herein, we present a [6+6] organoplatinum(II) metallacycle by using ~180° dipyridylanthracene donor and ~120° Pt(II) acceptor as the building blocks, which enables the capture and release of singlet oxygen with relatively high photooxygenation and thermolysis rate constants. The photooxygenation of the metallacycle to the corresponding endoperoxide was performed by sensitized irradiation, and the resulting endoperoxide is stable at room temperature and can be stored under ambient condition over months. Upon simple heating the neat endoperoxide under inert atmosphere at 120 °C for 4 h, the resulting endoperoxide can be reconverted to the corresponding parent form and singlet oxygen. The photooxygenation and thermolysis products were characterized by NMR spectroscopy and ESI-TOF-MS analysis. Density functional theory calculations were conducted in order to reveal the frontier molecular orbital interactions and reactivity. This work provides a new material-platform for singlet oxygen related promising applications.

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“…29,42,46,[49][50][51] Photodynamics is that the photosensitizer will produce single-line oxygen to directly kill tumor cells under the infrared light. 52 ICG has been approved by the US Food and Drug Administration, has significant near-infrared (NIR) optical properties, and is safe and non-toxic. 53,54 In this paper, a high molecular weight polymer dPSPs was prepared by cross-linking endogenous spermine through ROS/ GSH-sensitive cross-linking agent (-Se-Se-).…”

Section: Introductionmentioning

confidence: 99%

<p>Design and Fabrication of Dual Redox Responsive Nanoparticles with Diselenide Linkage Combined Photodynamically to Effectively Enhance Gene Expression</p>

Fang

Lin

Jin

et al. 2020

IJN

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Background PEI is currently the most used non-viral gene carrier and the transfection efficiency is closely related to the molecular weight; however, the prominent problem is that the cytotoxicity increased with the molecular weight. Methods A novel redox responsive biodegradable diselenide cross-linked polymer (dPSP) was designed to enhance gene expression. ICG-pEGFP-TRAIL/dPSP nanoparticles with high drug loading are prepared, which have redox sensitivity and plasmid protection. The transfection efficiency of dPSP nanoparticle was evaluated in vitro. Results The plasmid was compressed by 100% at the N/P ratio of 16, and the particle size was less than 100 nm. When explored onto high concentrations of GSH/H 2 O 2 , dPSP4 degraded into small molecular weight cationic substances with low cytotoxicity rapidly. Singlet oxygen ( 1 O 2 ) was produced when indocyanine green (ICG) was irradiated by near-infrared laser irradiation (NIR) to promote oxidative degradation of dPSP4 nanoparticles. Under the stimulation of NIR 808 and redox agent, the particle size and PDI of ICG-pDNA/dPSP nanoparticle increased significantly. Conclusion Compared with gene therapy alone, co-transportation of dPSP4 nanoparticle with ICG and pEGFP-TRAIL had better antitumor effect. Diselenide-crosslinked polyspermine had a promising prospect on gene delivery and preparation of multifunctional anti-tumor carrier.

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A Bifunctional Photosensitizer for Enhanced Fractional Photodynamic Therapy: Singlet Oxygen Generation in the Presence and Absence of Light

Cited by 51 publications

References 57 publications

Construction of Smart Manganese Dioxide‐Based All‐in‐One Nanoplatform for Cancer Diagnosis and Therapy

Construction of Smart Manganese Dioxide‐Based All‐in‐One Nanoplatform for Cancer Diagnosis and Therapy

Capture and Release of Singlet Oxygen in Coordination-Driven Self-Assembled Organoplatinum(II) Metallacycles

<p>Design and Fabrication of Dual Redox Responsive Nanoparticles with Diselenide Linkage Combined Photodynamically to Effectively Enhance Gene Expression</p>

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