A binary copper(II) complex having stepped polymeric structure: Synthesis, characterization, DNA-binding and anti-fungal studies

Abstract

A rarely found polymeric complex of copper(II) was obtained in the reaction of 2-(4-methylphenyl)acetate and copper sulfate and crystallized in quantitative yield. The complex was characterized using FT-IR, electron spin resonance, absorption spectroscopy, electrochemistry and powder and single crystal XRD studies. The structure was found to consist of interconnected paddlewheel units without an intervening ligand resulting in a stepped polymeric arrangement of the structure. The purity of the sample was judged from powder XRD data while ESR spectroscopy indicated a weak signal between 3000 and 4000 G values, indicating the presence of Cu(II) in the complex. Electrochemistry revealed an irreversible, predominantly diffusion controlled Cu II Cu II / /Cu II Cu I process with a D 0 value calculated to be 3.032×10-8 cm 2 s-1. The complex was screened for its DNA-binding ability through cyclic voltammetry, absorption and florescence spectroscopy and viscometry; the former two yielding K b values of 3.34×10 3 and 6.90×10 3 M-1 , respectively. The complex exhibited significant activity against fungal strain Mucor piriformis, moderate activity against Aspergillus niger and slight activity against Helminthosporium solani. These preliminary findings revealed the excellent biological potential of the synthesized complex.

Synthesis, characterization, antimicrobial screening and cytotoxic properties of Cu(II) and Zn(II) complexes with bidentate hydroxylated 1,3-diaryl-2-propene-1-ones ligand

“…19 Copper plays a key role in several enzymes and coenzyme in biochemical processes, because of its bio essentiality, its complexes are expected to be less toxic in recent medicinal complexes. 20 Zinc is another important transition metal in living organism which plays a critical role in physiological process. 21 Zinc can adopt different geometries with different coordination numbers; they have good pharmacological profiles 22 as anti-radio agents and tumour photosensitizes.…”

Synthesis, Characterization, DNA Binding and Cytotoxicity of Copper(II) Phenylcarboxylate Complexes

“…A small slope is observed, in agreement with the low Kb of the complexes, evidencing that the binding event is relatively minor compared to other Cu complexes and induces only small changes in DNA conformation. [54,55]. In particular, the binding of C3 on salmon sperm DNA was already reported and determined by the same methodology, with K b = 1.4 × 10 4 M -1 nm on the used DNA being suggestive of intercalation in addition to binding by the grooves [27].…”

“…Compound C1 C2 C3 L1 L2 L3 Kb (M-1) 5.2 × 10 2 2.0 × 10 2 8.7 × 10 2 ND * ND * ND * * Not Determined.The observed values of Kb are relatively low if compared with other Cu-carboxylate complexes. For instance, compounds [Cu2(nitrofenilacetate)4)(H2O)2] and [Cu2(fenilbutanoate)4]n present Kb values in the 10 3 -10 4 range[54,55]. In particular, the binding of C3 on salmon sperm DNA was already reported and determined by the same methodology, with Kb = 1.4 × 10 4 M -1 nm on the used DNA being suggestive of intercalation in addition to binding by the grooves[27].…”