A binuclear iron(III) complex of 5,5′-dimethyl-2,2′-bipyridine as cytotoxic agent

Kondori, Tahere; Torbati, Niloufar Akbarzadeh; Ghaznavi, Habib; Karimi, Zeinab; Shahraki, Javad; Sheervalilou, Roghayeh; Shahraki, Omolbanin

doi:10.1007/s10534-020-00255-z

Cited by 15 publications

(5 citation statements)

References 45 publications

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“…Iron is an essential element involved in diverse physiological processes, including DNA synthesis and oxygen binding [ 15 , 16 ]. Iron plays a beneficial role in intimal hyperplasia by antagonizing VSMC proliferation.…”

Section: Discussionmentioning

confidence: 99%

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Iron corroded granules inhibiting vascular smooth muscle cell proliferation

Qiu

Deng²,

Wen³

et al. 2022

Materials Today Bio

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Section: Discussionmentioning

confidence: 99%

“…Iron has demonstrated excellent biocompatibility and mechanical performance [ [12] , [13] , [14] ]. In addition, iron is an essential element involved in diverse physiological processes, including DNA synthesis and oxygen binding [ [15] , [16] , [17] ]. Moreover, iron played a beneficial role by antagonizing VSMC proliferation.…”

Section: Introductionmentioning

confidence: 99%

Iron corroded granules inhibiting vascular smooth muscle cell proliferation

Qiu

Deng²,

Wen³

et al. 2022

Materials Today Bio

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“…Meanwhile, groove binding and electrostatic interactions result in minimal or no DNA viscosity changes. 40,41…”

Section: Resultsmentioning

confidence: 99%

“…Meanwhile, groove binding and electrostatic interactions result in minimal or no DNA viscosity changes. 40,41 Fig. 2(a) illustrates the changes in DNA relative viscosity aer adding complexes 1a, 2a, and 2b.…”

Section: Dna Binding Studiesmentioning

confidence: 99%

Highly sensitive pork meat detection using copper(ii) tetraaza complex by electrochemical biosensor

et al. 2023

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“…A large number of studies have been conducted on wide-ranged applications of nanomaterials (NMs), only to discover their peculiarly unfavorable effects. In terms of cell function and molecular pathway, NMs often cause profound adverse biological effects (Setyawati et al 2013a;Tay et al 2013;Afzalipour et al 2019;Shirvalilou et al 2020;Kondori et al 2020). Nanotechnology has multiple applications with a scientific impact; however, the underlying pathways in interaction of NMs with biological systems at a molecular level still remain to be elucidated.…”

Section: Nanotechnologymentioning

confidence: 99%

An Updated Review on Implications of Autophagy and Apoptosis in Tumorigenesis: Possible Alterations in Autophagy through Engineered Nanomaterials and Their Importance in Cancer Therapy

et al. 2021

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Most commonly recognized as a catabolic pathway, autophagy is a perplexing mechanism through which a living cell can free itself of excess cytoplasmic components, i.e., organelles, by means of certain membranous vesicles or lysosomes filled with degrading enzymes. Upon exposure to external insult or internal stimuli, the cell might opt to activate such pathway through which it can gain control over the maintenance of intracellular components, and thus, sustain homeostasis by intercepting the formation of unnecessary structures or elimination of the already present dysfunctional or inutile organelles. Despite such appropriateness, autophagy, might also be considered a frailty for the cell, as it has been said to have a rather complicated role in tumorigenesis. A merit in the early stages of tumor formation, autophagy appears to be salutary due to its tumor-suppressing effects. In fact, several investigations on tumorigenesis have reported diminished levels of autophagic activity in tumor cells, which might result in transition to malignancy. On the contrary, autophagy has been suggested to be a seemingly favorable mechanism to progressed malignancies, as it contributes to survival of such cells. Based on the recent literature, this mechanism might also be activated upon the entry of engineered nanomaterials inside a cell, supposedly protecting the host from foreign materials. Accordingly, there is a good chance that therapeutic interventions for modulating autophagy in malignant cells using nanoparticles may sensitize cancerous cells to certain treatment modalities, e.g., radiotherapy. In this review, we will discuss the signaling pathways involved in autophagy, and the significance of the mechanism itself in apoptosis and tumorigenesis, while shedding light on possible alterations in autophagy through engineered nanomaterials, and the their potential therapeutic applications in cancer.

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A binuclear iron(III) complex of 5,5′-dimethyl-2,2′-bipyridine as cytotoxic agent

Cited by 15 publications

References 45 publications

Iron corroded granules inhibiting vascular smooth muscle cell proliferation

Iron corroded granules inhibiting vascular smooth muscle cell proliferation

Highly sensitive pork meat detection using copper(ii) tetraaza complex by electrochemical biosensor

An Updated Review on Implications of Autophagy and Apoptosis in Tumorigenesis: Possible Alterations in Autophagy through Engineered Nanomaterials and Their Importance in Cancer Therapy

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