A bioactive exopolysaccharide from marine bacteria Alteromonas sp. PRIM-28 and its role in cell proliferation and wound healing in vitro

Sahana, T. G.; Rekha, P. D.

doi:10.1016/j.ijbiomac.2019.03.048

Cited by 49 publications

(28 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SpainFTIR (Fourier Transform Infrared) analysis was carried out to evaluate the interactions between chitosan and EPS. Regarding EPS ( Figure 2 a), the main characteristic bands appeared at 3300 cm −1 , corresponding to O-H stretching; at 1633 cm −1 , associated to C=O stretching; around 1400 cm −1 , corresponding to C-H stretching vibrations in hexoses; at 1230 cm −1 , associated to the presence of sulfates; at 1100 cm −1 , due to glycosidic linkages; and at 1000 cm −1 , related to C-O stretching [ 14 ]. The most relevant difference between the two EPS was related to the difference in the relative intensity between the bands at 1633 and 1400 cm −1 .…”

Section: Resultsmentioning

confidence: 99%

“…EPS derived from marine bacteria are currently attracting substantial attention [13] as they show interesting properties. These EPS include atypical sugar monomers, such as fructose and rhamnose [14], which are of commercial interest, and they typically contain several organic and inorganic substitutes that modulate their physicochemical properties. For instance, the adhesive and viscous properties of EPS are attributed to the presence of uronic acids, sulphates, or carboxyl groups that confer anionic properties to the polymer [15].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Chitosan Films Incorporated with Exopolysaccharides from Deep Seawater Alteromonas sp.

Zarandona

Estupiñán²,

Perez³

et al. 2020

Marine Drugs

View full text Add to dashboard Cite

Two Alteromonas sp. strains isolated from deep seawater were grown to promote the production of exopolysaccharides (EPS, E611 and E805), which were incorporated into chitosan solutions to develop films. The combination of the major marine polysaccharides (chitosan and the isolated bacterial EPS) resulted in the formation of homogenous, transparent, colorless films, suggesting good compatibility between the two components of the film-forming formulation. With regards to optical properties, the films showed low values of gloss, in the range of 5–10 GU, indicating the formation of non-glossy and rough surfaces. In addition to the film surface, both showed hydrophobic character, with water contact angles higher than 100 º, regardless of EPS addition. Among the two EPS under analysis, chitosan films with E805 showed better mechanical performance, leading to resistant, flexible, easy to handle films.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chitosan Films Incorporated with Exopolysaccharides from Deep Seawater Alteromonas sp.

Zarandona

Estupiñán²,

Perez³

et al. 2020

Marine Drugs

View full text Add to dashboard Cite

show abstract

“…The modern world pharmaceutical market offers a great variety of different types of alginate-based bandages, from traditional hydrogel dressings to innovative lyophilized sheets and nanofibers for cavity wounds [27,46,[95][96][97], as well as combined designs of these polysaccharides with Zn, Mn, Ag, glycerol, polyvinyl alcohol, and other marine-derived polymers [94,[98][99][100].…”

Section: Alginatesmentioning

confidence: 99%

“…Duration of the phases and sequence of the healing stages can be disturbed by a number of local and systemic factors (compression, diseases such as diabetes mellitus, hypoxia, necrosis, excessive accumulation of reactive oxygen species). A long-lasting and incomplete healing process causes chronic, recurrent, or long-term non-healing wounds (from 12 weeks or more), which often do not reach functional and anatomical recovery even after a long-term treatment [ 5 , 12 , 40 , 46 ].…”

Section: Introductionmentioning

confidence: 99%

“…In recent decades, a significant number of experimental and clinical studies have been conducted to clarify the ability of marine biopolymers (alginates, ulvans, chitosan, chitin, carrageenans, fucoidans, etc.) to modulate certain phases of the wound healing process [ 2 , 16 , 19 , 20 , 30 , 44 , 45 , 46 , 48 ]. Their significant potential to influence the focus of injury by inhibiting inflammation, activating fibroblast proliferation, and remodeling tissues has been revealed.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Sulfated Polysaccharides from Marine Algae as a Basis of Modern Biotechnologies for Creating Wound Dressings: Current Achievements and Future Prospects

et al. 2020

View full text Add to dashboard Cite

Wound healing involves a complex cascade of cellular, molecular, and biochemical responses and signaling processes. It consists of successive interrelated phases, the duration of which depends on a multitude of factors. Wound treatment is a major healthcare issue that can be resolved by the development of effective and affordable wound dressings based on natural materials and biologically active substances. The proper use of modern wound dressings can significantly accelerate wound healing with minimum scar mark. Sulfated polysaccharides from seaweeds, with their unique structures and biological properties, as well as with a high potential to be used in various wound treatment methods, now undoubtedly play a major role in innovative biotechnologies of modern natural interactive dressings. These natural biopolymers are a novel and promising biologically active source for designing wound dressings based on alginates, fucoidans, carrageenans, and ulvans, which serve as active and effective therapeutic tools. The goal of this review is to summarize available information about the modern wound dressing technologies based on seaweed-derived polysaccharides, including those successfully implemented in commercial products, with a focus on promising and innovative designs. Future perspectives for the use of marine-derived biopolymers necessitate summarizing and analyzing results of numerous experiments and clinical trial data, developing a scientifically substantiated approach to wound treatment, and suggesting relevant practical recommendations.

show abstract

Polysaccharides and Peptides With Wound Healing Activity From Bacteria and Fungi

Arslan,

Orak,

Ozdemir

et al. 2024

Journal of Basic Microbiology

View full text Add to dashboard Cite

Bacteria and fungi are natural sources of metabolites exhibiting diverse bioactive properties such as wound healing, antioxidative, antibacterial, antifungal, anti‐inflammatory, antidiabetic, and anticancer activities. Two important groups of bacteria or fungi‐derived metabolites with wound‐healing potential are polysaccharides and peptides. In addition to bacteria‐derived cellulose and hyaluronic acid and fungi‐derived chitin and chitosan, these organisms also produce different polysaccharides (e.g., exopolysaccharides) with wound‐healing potential. The most commonly used bacterial peptides in wound healing studies are bacteriocins and lipopeptides. Bacteria or fungi‐derived polysaccharides and peptides exhibit both the in vitro and the in vivo wound healing potency. In the in vivo models, including animals and humans, these metabolites positively affect wound healing by inhibiting pathogens, exhibiting antioxidant activity, modulating inflammatory response, moisturizing the wound environment, promoting the proliferation and migration of fibroblasts and keratinocytes, increasing collagen synthesis, re‐epithelialization, and angiogenesis. Therefore, peptides and polysaccharides derived from bacteria and fungi have medicinal importance. This study aims to overview current literature knowledge (especially within the past 5 years) on the in vitro and in vivo wound repair potentials of polysaccharides and peptides obtained from bacteria (Actinobacteria, Bacteroidetes, Cyanobacteria, Firmicutes, and Proteobacteria) and fungi (yeasts, filamentous microfungi, and mushrooms).

show abstract

A bioactive exopolysaccharide from marine bacteria Alteromonas sp. PRIM-28 and its role in cell proliferation and wound healing in vitro

Cited by 49 publications

References 52 publications

Chitosan Films Incorporated with Exopolysaccharides from Deep Seawater Alteromonas sp.

Chitosan Films Incorporated with Exopolysaccharides from Deep Seawater Alteromonas sp.

Sulfated Polysaccharides from Marine Algae as a Basis of Modern Biotechnologies for Creating Wound Dressings: Current Achievements and Future Prospects

Polysaccharides and Peptides With Wound Healing Activity From Bacteria and Fungi

Contact Info

Product

Resources

About