A bioactive glass nanocomposite scaffold toughed by multi-wall carbon nanotubes for tissue engineering

Liu, Jinglin; Gao, Chengde; Feng, Pei; Xiao, Tao; Shuai, Cijun; Peng, Shuping

doi:10.2109/jcersj2.123.485

Cited by 16 publications

(5 citation statements)

References 39 publications

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“…Ball milling is a high-energy technique in which collisions between small rigid spheres generate extreme pressures capable of dispersing CNT within matrix materials. In one instance, ball milling was used in conjunction with ultrasonication to toughen a bioactive glass nanocomposite scaffold with CNT ( Liu et al, 2015 ). An ultrasonicated CNT-ethanol solution was mixed with bioactive glass nanoparticles, and the wet mixture was subject to a high energy ball milling machine.…”

Section: Fabrication Of Cnt-based Scaffoldsmentioning

confidence: 99%

Carbon nanotube nanocomposite scaffolds: advances in fabrication and applications for tissue regeneration and cancer therapy

Shar,

Joung

2023

Front. Bioeng. Biotechnol.

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Carbon nanotube (CNT) nanocomposite scaffolds have emerged as highly promising frameworks for tissue engineering research. By leveraging their intrinsic electrical conductivity and valuable mechanical properties, CNTs are commonly dispersed into polymers to create robust, electrically conductive scaffolds that facilitate tissue regeneration and remodeling. This article explores the latest progress and challenges related to CNT dispersion, functionalization, and scaffold printing techniques, including electrospinning and 3D printing. Notably, these CNT scaffolds have demonstrated remarkable positive effects across various cell culture systems, stimulating neuronal growth, promoting cardiomyocyte maturation, and facilitating osteocyte differentiation. These encouraging results have sparked significant interest within the regenerative medicine field, including neural, cardiac, muscle, and bone regenerations. However, addressing the concern of CNT cytotoxicity in these scaffolds remains critical. Consequently, substantial efforts are focused on exploring strategies to minimize cytotoxicity associated with CNT-based scaffolds. Moreover, researchers have also explored the intriguing possibility of utilizing the natural cytotoxic properties of CNTs to selectively target cancer cells, opening up promising avenues for cancer therapy. More research should be conducted on cutting-edge applications of CNT-based scaffolds through phototherapy and electrothermal ablation. Unlike drug delivery systems, these novel methodologies can combine 3D additive manufacturing with the innate physical properties of CNT in response to electromagnetic stimuli to efficiently target localized tumors. Taken together, the unique properties of CNT-based nanocomposite scaffolds position them as promising candidates for revolutionary breakthroughs in both regenerative medicine and cancer treatment. Continued research and innovation in this area hold significant promise for improving healthcare outcomes.

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Section: Fabrication Of Cnt-based Scaffoldsmentioning

confidence: 99%

Carbon nanotube nanocomposite scaffolds: advances in fabrication and applications for tissue regeneration and cancer therapy

Shar,

Joung

2023

Front. Bioeng. Biotechnol.

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“…Results showed that both CNTs-HA and graphene-HA materials supported cell growth and differentiation. Liu et al [191] used CNTs as reinforcement fillers to enhance the mechanical properties of bioglass scaffolds including compressive strength (maximum value of 37.32 MPa for samples containing 3 wt% of CNTs) and fracture toughness (maximum value of 1.58 MPa m 1/2 for samples containing 3wt% of CNTs). Scaffolds were produced using a powderbed fusion additive manufacturing system.…”

Section: Bone Tissue Engineeringmentioning

confidence: 99%

Carbon nanotubes and their polymeric composites: the applications in tissue engineering

Huang

2020

Biomanuf Rev

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Carbon nanotubes (CNTs), with unique graphitic structure, superior mechanical, electrical, optical and biological properties, has attracted more and more interests in biomedical applications, including gene/drug delivery, bioimaging, biosensor and tissue engineering. In this review, we focus on the role of CNTs and their polymeric composites in tissue engineering applications, with emphasis on their usages in the nerve, cardiac and bone tissue regenerations. The intrinsic natures of CNTs including their physical and chemical properties are first introduced, explaining the structure effects on CNTs electrical conductivity and various functionalization of CNTs to improve their hydrophobic characteristics. Biosafety issues of CNTs are also discussed in detail including the potential reasons to induce the toxicity and their potential strategies to minimise the toxicity effects. Several processing strategies including solution-based processing, polymerization, melt-based processing and grafting methods are presented to show the 2D/3D construct formations using the polymeric composite containing CNTs. For the sake of improving mechanical, electrical and biological properties and minimising the potential toxicity effects, recent advances using polymer/CNT composite the tissue engineering applications are displayed and they are mainly used in the neural tissue (to improve electrical conductivity and biological properties), cardiac tissue (to improve electrical, elastic properties and biological properties) and bone tissue (to improve mechanical properties and biological properties). Current limitations of CNTs in the tissue engineering are discussed and the corresponded future prospective are also provided. Overall, this review indicates that CNTs are promising “next-generation” materials for future biomedical applications.

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“…However, when the amount of nanomaterial was greater than an optimum level of loading (different in each case), the effect was reduced. Liu et al [ 277 ] reported that 3 wt.% MWCNTs presented the most pronounced effect in terms of mechanical properties for BG-based scaffolds. In the case of Di, following the study by Shuai et al [ 278 ], this level of loading was reduced to 2 wt.% MWCNTs.…”

Section: 3d Printed Scaffolds With Carbon-based Nanomaterialsmentioning

confidence: 99%

Advances in Biodegradable 3D Printed Scaffolds with Carbon-Based Nanomaterials for Bone Regeneration

et al. 2020

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Bone possesses an inherent capacity to fix itself. However, when a defect larger than a critical size appears, external solutions must be applied. Traditionally, an autograft has been the most used solution in these situations. However, it presents some issues such as donor-site morbidity. In this context, porous biodegradable scaffolds have emerged as an interesting solution. They act as external support for cell growth and degrade when the defect is repaired. For an adequate performance, these scaffolds must meet specific requirements: biocompatibility, interconnected porosity, mechanical properties and biodegradability. To obtain the required porosity, many methods have conventionally been used (e.g., electrospinning, freeze-drying and salt-leaching). However, from the development of additive manufacturing methods a promising solution for this application has been proposed since such methods allow the complete customisation and control of scaffold geometry and porosity. Furthermore, carbon-based nanomaterials present the potential to impart osteoconductivity and antimicrobial properties and reinforce the matrix from a mechanical perspective. These properties make them ideal for use as nanomaterials to improve the properties and performance of scaffolds for bone tissue engineering. This work explores the potential research opportunities and challenges of 3D printed biodegradable composite-based scaffolds containing carbon-based nanomaterials for bone tissue engineering applications.

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A bioactive glass nanocomposite scaffold toughed by multi-wall carbon nanotubes for tissue engineering

Cited by 16 publications

References 39 publications

Carbon nanotube nanocomposite scaffolds: advances in fabrication and applications for tissue regeneration and cancer therapy

Carbon nanotube nanocomposite scaffolds: advances in fabrication and applications for tissue regeneration and cancer therapy

Carbon nanotubes and their polymeric composites: the applications in tissue engineering

Advances in Biodegradable 3D Printed Scaffolds with Carbon-Based Nanomaterials for Bone Regeneration

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