“…The second model focuses on the action of intrinsic growth factors that would directly cause thickening of blood vessels and the left ventricle at all stages of the disease~Folkow, 1990; Lee, Bohm, Paul, & Ganten, 1993;Lovallo & Wilson, 1992a, 1992b in the presence of normal hemodynamic stimuli~Anversa, Capasso, Olivetti, & Sonnenblick, 1992;Bergbrant, Hansson, & Jern, 1993;Korner, Angus, Bobik, & Jennings, 1991!. These morphologic changes appear to precede significant BP elevations~Devereux, de Simone, Koren, Roman, & Laragh, 1991;Frohlich et al, 1992!…”