A biocompatible calcium salt of hyaluronic acid grafted with polyacrylic acid

Cationic Salecan-based hydrogels for release of 5-fluorouracil

“…6,10,11 In recent decades, natural polymers such as polysaccharides, have frequently been used to design intelligent hydrogel drug carriers (reserving drugs in a de-swollen state and releasing drugs in a swollen state) owing to their superior physiochemical and biological properties (e.g., biodegradability, renewability and biocompatibility). 12,13 However, polysaccharide-based hydrogel drug devices have two signicant inherent limitations: one is the poor mechanical strength, and the other is the lack of sustained release ability. 14 Typically, drugs are wrapped in the hydrogel matrices by simple physical forces only, resulting in a burst release of encapsulated drugs because of the relatively weak intermolecular interactions between hydrogels and drugs.…”

“…17,18 Gra copolymerization is an effective and versatile approach to modify the architecture of native polysaccharides. 13 This technique greatly enlarges the applications of polysaccharideconstructed hydrogels. 14,19 For instance, various synthetic polymers including [2-(methacryloxy)ethyl]trimethylammonium chloride, 20 N-isopropylacrylamide 4 and acrylic acid, 15 have been successfully introduced into the polysaccharide skeleton.…”

Crosslinking method of hyaluronic-based hydrogel for biomedical applications

“…On the other hand, the degradation rate of HA- g -PAA was much slower than native HA in the presence of HAse. 91 …”

“…On the other hand, the degradation rate of HA-g-PAA was much slower than native HA in the presence of HAse. 91 Photo-crosslink hydrogel. For cartilage tissue engineering, an injectable hydrogel consisting of methacrylated glycol chitosan (MeGC) and HA was created by photo-crosslinking with a riboflavin photo-initiator.…”

Development of hyaluronic acid derivatives for applications in biomedical engineering

“…In the work of Nakagawa et al HA is first grafted to the polyacrylic acid and then crosslinked in presence of calcium chloride [75]. The resulting gel has lower viscosity and slower degradation rate compared to the pristine HA.…”