A Biocompatible Heterogeneous MOF–Cu Catalyst for In Vivo Drug Synthesis in Targeted Subcellular Organelles

Wang, Faming; Zhang, Yan; Liu, Zhengwei; Du, Zhi; Zhang, Lu; Ren, Jinsong; Qu, Xiaogang

doi:10.1002/ange.201901760

Cited by 42 publications

(15 citation statements)

References 70 publications

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“…Thus,i n2 019, this group developed ac atalyst based on aM OF support that holds and stabilizes ultrasmall copper(0) nanoparticles at their inner cavities (5-10 wt %). [37] Interestingly,b yd ecorating the resulting MOF-Cu particles with at riphenylphosphonium vector (MOF-Cu-TPP,F igure 5B), the authors showed that they can preferentially accumulate in the mitochondria of living cells, wherein they remaina ctive. As ar esult, this strategy allowed the mitochondria-localized generation of ar esveratrol-derived drug from their respective azide and alkynep recursors .…”

Section: Copper(i)-promoted Azide-alkyne Cycloaddition (Cuaac)mentioning

confidence: 99%

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Transition Metal‐Promoted Reactions in Aqueous Media and Biological Settings

Destito

Vidal

López

et al. 2021

Chemistry A European J

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During the last decade, there has been a tremendous interest for developing non‐natural biocompatible transformations in biologically relevant media. Among the different encountered strategies, the use of transition metal complexes offers unique possibilities due to their high transformative power. However, translating the potential of metal catalysts to biological settings, including living cells or small‐animal models such as mice or zebrafish, poses numerous challenges associated to their biocompatibility, and their stability and reactivity in crowded aqueous environments. Herein, we describe the most relevant advances in this direction, with a particular emphasis on the systems’ structure, their mode of action and the mechanistic bases of each transformation. Thus, the key challenges from an organometallic perspective might be more easily identified.

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Section: Copper(i)-promoted Azide-alkyne Cycloaddition (Cuaac)mentioning

confidence: 99%

“…Heterogeneous Cu-based nanoconstructs for bioorthogonal CuAACs. Figure5Ba dapted with permission from ref [37]…”

mentioning

confidence: 99%

Transition Metal‐Promoted Reactions in Aqueous Media and Biological Settings

Destito

Vidal

López

et al. 2021

Chemistry A European J

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“…lysosomes, mitochondria and nucleus etc.) via multiple mechanisms (Chakraborty et al, 2018;Wang F. et al, 2019;Yuanjie Zhu and Yuanjie Zhu, 2019;Guo et al, 2020).…”

Section: Current Scenario Of Subcellular Drug Targetingmentioning

confidence: 99%

“…The reaction system developed various advantages such as the avoidance of the troublesome delivery process and non-specific distribution of obnoxious moieties, possibilities of multi-drug synthesis, and high biocompatibility etc. (Wang F. et al, 2019). Similarly, another functionalized colloidal nanoparticulate system with chemical and biochemical surface functionalization was developed, which took into account the recent concept of nanoprobes.…”

Section: Current Scenario Of Subcellular Drug Targetingmentioning

confidence: 99%

Membrane Trafficking and Subcellular Drug Targeting Pathways

Kumar¹,

Ahmad²,

Vyawahare³

et al. 2020

Front. Pharmacol.

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The movement of micro and macro molecules into and within a cell significantly governs several of their pharmacokinetic and pharmacodynamic parameters, thus regulating the cellular response to exogenous and endogenous stimuli. Trafficking of various pharmacological agents and other bioactive molecules throughout and within the cell is necessary for the fidelity of the cells but has been poorly investigated. Novel strategies against cancer and microbial infections need a deeper understanding of membrane as well as subcellular trafficking pathways and essentially regulate several aspects of the initiation and spread of anti-microbial and anti-cancer drug resistance. Furthermore, in order to avail the maximum possible bioavailability and therapeutic efficacy and to restrict the unwanted toxicity of pharmacological bioactives, these sometimes need to be functionalized with targeting ligands to regulate the subcellular trafficking and to enhance the localization. In the recent past the scenario drug targeting has primarily focused on targeting tissue components and cell vicinities, however, it is the membranous and subcellular trafficking system that directs the molecules to plausible locations. The effectiveness of the delivery platforms largely depends on their physicochemical nature, intracellular barriers, and biodistribution of the drugs, pharmacokinetics and pharmacodynamic paradigms. Most subcellular organelles possess some peculiar characteristics by which membranous and subcellular targeting can be manipulated, such as negative transmembrane potential in mitochondria, intraluminal delta pH in a lysosome, and many others. Many specialized methods, which positively promote the subcellular targeting and restrict the off-targeting of the bioactive molecules, exist. Recent advancements in designing the carrier molecules enable the handling of membrane trafficking to facilitate the delivery of active compounds to subcellular localizations. This review aims to cover membrane trafficking pathways which promote the delivery of the active molecule in to the subcellular locations, the associated pathways of the subcellular drug delivery system, and the role of the carrier system in drug delivery techniques.

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“…Beyond being an excellent protective matrix for biomolecules, a variety of applications have recently emerged from the biocatalysts-MOF interfac (Figure 1) For instance, the facile surface functionalization, [24] stimuli-responsive behavior, [25,26] and some enzyme-mimicking characteristics [27,28] of MOFs enable innovative applications of the engineering MOFs with enzymes for smart catalysis. Furthermore, their high biomolecule loading capacity, biodegradability, controlled release property, stimuli-responsive characteristics, and high biocompatibility in vitro and in vivo [29][30][31][32] are prone to be a versatile nanoplatform for biocatalysts delivery and catalytic nanomedicine. By integrating site-responsive materials (e.g.…”

Section: Introductionmentioning

confidence: 99%

Biocatalytic Metal–Organic Frameworks: Prospects Beyond Bioprotective Porous Matrices

Liang

2020

Adv Funct Materials

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Biocatalytic metal-organic framework (MOF) composites, synthesized by interfacing MOFs with biocatalytic components, possess the unprecedented synergetic properties that is hard to achieve by the conventional strategies, represents one of the next-generation composite materials for diverse biotechnological applications. Until now , research on the applications of biocatalytic MOFs is still in its preliminary stage, with a wide variety of studies being focusing on the bioprotection role of MOFs. However, their diversity of building units, molecular-scale tunability, modular synthetic routes, and more detailed understanding of the heterogeneous MOF-biointerface could even lead to completely new applications and potentials beyond our current imagination. The most recent rapid advanced progress in biocatalytic MOFs present ground-breaking applications in smart and tunable biocatalysis, precision nanomedicine, vaccine and gene delivery, biosensing and nano-biohybrids. Herein, the general and advanced synthesis strategies for improving the materials properties of biocatalytic MOFs, from tuning biocatalytic activity to framework stability to synergistic properties with other materials, are summarized. Then, the latest state-of-the-art applications of the biocatalytic MOF systems and recent advanced developments that are shaping this emerging field are surveyed. Finally, to define promising research directions, a critical evaluation and future prospects for the potential applications of biocatalytic MOFs are provided.

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A Biocompatible Heterogeneous MOF–Cu Catalyst for In Vivo Drug Synthesis in Targeted Subcellular Organelles

Cited by 42 publications

References 70 publications

Transition Metal‐Promoted Reactions in Aqueous Media and Biological Settings

Transition Metal‐Promoted Reactions in Aqueous Media and Biological Settings

Membrane Trafficking and Subcellular Drug Targeting Pathways

Biocatalytic Metal–Organic Frameworks: Prospects Beyond Bioprotective Porous Matrices

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