A biocompatible nano-barium sulfonate system for quad-modal imaging-guided photothermal radiotherapy of tumors

Lian, Yunfei; Feng, Felix Y.; Meng, Xue; Hu, Yue; Huo, Meirong; Wang, Guangji; Li, Chang Ming

doi:10.1039/d3bm00325f

Cited by 4 publications

(1 citation statement)

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“…ICG could generate fluorescence, hyperthermia and singlet oxygen upon 808 nm laser irradiation, which allows ICG to be used for molecular imaging and phototherapy in cancer diagnosis and therapeutics (Chen et al., 2016; Hong et al., 2022; Pollmann et al., 2023). Besides, ICG has been widely investigated to combine with other therapeutics such as immunotherapy, chemotherapy and radiotherapy to better suppress cancer (Lian et al., 2023; Lu et al., 2023; Sun et al., 2022; Tu et al., 2020). However, ICG exhibits poor stability in aqueous solution and short plasma half‐life time in vivo, which significantly limit its applications for both cancer diagnosis and therapeutics (Hu, Chen, et al., 2019; Hu et al., 2017; Saxena et al., 2003).…”

Section: Introductionmentioning

confidence: 99%

Biotin‐new indocyanine green conjugate: Synthesis, in vitro photocytotoxicity and in vivo biodistribution

Liu,

Ding,

et al. 2024

Chem Biol Drug Des

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New indocyanine green (ICG) (IR820) is one of the ICG derivatives and attracts increasing attention for cancer management. However, the unsatisfactory tumor targeting ability of IR820 significantly limits its applications for cancer theranostics. Biotin receptor is overexpressed on the membrane of various tumor cells and biotin modified nanocarriers have been reported to enhance the tumor targeting ability on several tumor types. In this work, biotin‐new ICG conjugate (Biotin‐SS‐IR820) was prepared for tumor‐targeted IR820 delivery. Biotin and IR820 were coupled through cystamine. The synthesized Biotin‐SS‐IR820 was characterized by 1H NMR, FT‐IR and HRMS. The in vitro singlet oxygen generation study shows that Biotin‐SS‐IR820 exhibits similar singlet oxygen generation as compared to IR820 upon 660 nm laser irradiation (0.8 W/cm2). The cellular uptake study shows that Biotin‐SS‐IR820 shows enhanced cellular uptake amount as compared to IR820 on 4T1 cells. As a result, Biotin‐SS‐IR820 displays enhanced in vitro photodynamic therapeutic effect against 4T1 cells as compared to IR820. In in vivo biodistribution study, Biotin‐SS‐IR820 shows enhanced tumor accumulation as compared to IR820. Biotin‐SS‐IR820 developed in this work shows promising prospects for targeted delivery of IR820 to biotin receptor overexpressed tumors.

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Section: Introductionmentioning

confidence: 99%

Biotin‐new indocyanine green conjugate: Synthesis, in vitro photocytotoxicity and in vivo biodistribution

Liu,

Ding,

et al. 2024

Chem Biol Drug Des

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CT‐Visible Microspheres Enable Whole‐Body In Vivo Tracking of Injectable Tissue Engineering Scaffolds

Bettini,

Patrick,

Day

et al. 2024

Adv Healthcare Materials

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Targeted delivery and retention is an essential requirement for implantable tissue engineered products. Non‐invasive imaging methods that can confirm location, retention and biodistribution of transplanted cells attached to implanted tissue engineering scaffolds would be invaluable for the optimisation and enhancement of regenerative therapies. To address this need, an injectable tissue engineering scaffold consisting of highly porous microspheres compatible with transplantation of cells was modified to contain the computed tomography (CT) contrast agent barium sulphate (BaSO4). The trackable microspheres showed high x‐ray absorption, with contrast permitting whole‐body tracking. The microspheres were cellularised with GFP+ Luciferase+ mesenchymal stem cells and showed in vitro biocompatibility. In vivo, cellularised BaSO4‐loaded microspheres were delivered into the hindlimb of mice where they remained viable for 14 days. Co‐registration of 3D‐BLI and μCT reconstructions enabled assessment of scaffold material and cell co‐localization. The trackable microspheres were also compatible with minimally‐invasive delivery by ultrasound‐guided transthoracic intramyocardial injections in rats. These findings suggest that BaSO4‐loaded microspheres can be used as a novel tool for optimising delivery techniques and tracking persistence and distribution of implanted scaffold materials. Additionally, the microspheres can be cellularised and have the potential to be developed into an injectable tissue engineered combination product for cardiac regeneration.This article is protected by copyright. All rights reserved

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Improved photothermal properties of a functionalized polydopamine mediated by chelating iron ions

Yuan,

Li,

et al. 2024

Materialia

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A biocompatible nano-barium sulfonate system for quad-modal imaging-guided photothermal radiotherapy of tumors

Abstract: Integration of multi-modal imaging techniques and various cancer treatments based on their respective characteristics would be beneficial to enhance anticancer efficacy. Exploiting an “all-in-one” nanoparticle with high biocompatibility has attracted...

Cited by 4 publications

References 42 publications

Biotin‐new indocyanine green conjugate: Synthesis, in vitro photocytotoxicity and in vivo biodistribution

Biotin‐new indocyanine green conjugate: Synthesis, in vitro photocytotoxicity and in vivo biodistribution

CT‐Visible Microspheres Enable Whole‐Body In Vivo Tracking of Injectable Tissue Engineering Scaffolds

Improved photothermal properties of a functionalized polydopamine mediated by chelating iron ions

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