A biocompatible pure organic porous nanocage for enhanced photodynamic therapy

Abstract

Porphyrin-based photosensitizers have been widely utilized in photodynamic therapy (PDT), but suffer from deteriorating fluorescence and reactive oxygen species (ROS) due to the close π-π stacking. Herein, a biocompatible pure...

Iron(ii)-catalyzed annulation to construct novel quinone-fused cyclopenta[2,1-b]indoles: a promising type I photosensitizer

“…[13][14][15] Therefore, quinones, with appropriate redox potential, perfectly fit the above direct principle for construction of type I PSs. However, unlike porphyrins, which are widely used in the field of PDT, [16][17][18] existing quinones and their derivatives are less involved as PSs because of the difficulty of synthesis and short excitation wavelength. It is imperative to develop new facile quinone design and synthesis strategies to obtain type I PSs with near-infrared (NIR) absorption.…”

High Singlet Oxygen Generating Benzothienyl‐[b]‐fused BODIPY Nanoaggregates and Photoinduced Apoptosis in Human Carcinoma

“…[35,36] Porphyrin-based PSs showed enhanced 1 O 2 generation when immobilized on silica nanoparticles. [37,38] Recently, porous cage of PS was suggested for better efficacy in PDT. [39] To contribute in this direction, herein, we synthesized 8-thienyl bisbenzothieno [b]-fused BODIPY (BT- [b]-fused BODIPY, (Chart1) and investigated it for PDT applications using MCF-7 and A549 cancer cell lines.…”

Enhancing Surface Hydroxyl Group Modulation on Carbon Nitride Boosts the Effectiveness of Photodynamic Treatment for Brain Glioma

“…In addition, traditional photosensitizers (porphyrins derivatives) usually have planar and extended hydrophobic conjugated π−π structures, resulting in a weakened fluorescence signal and ROS production ability in aqueous media. 17 Although the metalbased PS has a strong light absorption and ROS production capacity, its biosafety needs to be improved. 18 Therefore, it is imperative to find a PS with strong biosafety and a high ROS production rate.…”

“…However, due to the lack of deep tissue excitable PS and appropriate strategies, the application of PDT in glioma treatment is challenging. In addition, traditional photosensitizers (porphyrins derivatives) usually have planar and extended hydrophobic conjugated π–π structures, resulting in a weakened fluorescence signal and ROS production ability in aqueous media . Although the metal-based PS has a strong light absorption and ROS production capacity, its biosafety needs to be improved .…”