2020
DOI: 10.1007/s10853-020-05205-1
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A biodegradable core-sheath nanofibrous 3D hierarchy prepared by emulsion electrospinning for sustained drug release

Abstract: A sustained release system that composed of biodegradable core-sheath nanofibers in 3D hierarchy has been developed through electrospinning of water-inoil precursor emulsion, in which theophylline dissolved in water was labeled as 'aqueous phase' and PLA solution was considered as 'organic phase'. SEM images revealed that the fibers crossed and overlapped with each other, forming a 3D network-like structure. TEM indicated that the drug was well incorporated into PLA nanofibers, forming a core-sheath structure,… Show more

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Cited by 19 publications
(7 citation statements)
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“…Various polymers from the group of both synthetic and natural polymers have been used as carriers for introducing the active agent into the aqueous phase with the aid of either an aqueous or polymer solution. The emulsion electrospinning method have been used to encapsulate the drug (theophylline) in PLA fibers [ 33 ], antimicrobial agent ( C. majus ) in PCL/PVA_PEC (polycaprolactone/polyvinyl alcohol pectin) fibers [ 34 ], or growth factors into PLACL (poly(l-lactide-co-caprolactone)) [ 35 ] and PDLLA/PLGA [ 36 ]. These materials also include nonwovens based on polymers, such as PCL consisting of tramadol + PEO [ 37 ], L-ascorbic acid 2-phosphate magnesium (ASP) for osteogenic differentiation [ 38 ], hyaluronic acid [ 39 ], or silk fibroin [ 31 ] in either the core or shell part.…”
Section: Introductionmentioning
confidence: 99%
“…Various polymers from the group of both synthetic and natural polymers have been used as carriers for introducing the active agent into the aqueous phase with the aid of either an aqueous or polymer solution. The emulsion electrospinning method have been used to encapsulate the drug (theophylline) in PLA fibers [ 33 ], antimicrobial agent ( C. majus ) in PCL/PVA_PEC (polycaprolactone/polyvinyl alcohol pectin) fibers [ 34 ], or growth factors into PLACL (poly(l-lactide-co-caprolactone)) [ 35 ] and PDLLA/PLGA [ 36 ]. These materials also include nonwovens based on polymers, such as PCL consisting of tramadol + PEO [ 37 ], L-ascorbic acid 2-phosphate magnesium (ASP) for osteogenic differentiation [ 38 ], hyaluronic acid [ 39 ], or silk fibroin [ 31 ] in either the core or shell part.…”
Section: Introductionmentioning
confidence: 99%
“…O/W emulsion electrospinning enables the incorporation of hydrophobic molecules into hydrophilic polymers by improving its solubility, while W/O emulsion electrospinning is available to incorporate hydrophilic substances into hydrophobic polymers for the purpose of avoiding a loss of bioactivity and burst release . As such , W/O emulsion is the choice for more studies to fabricate PLA-based composite nanofibers, especially those containing water-soluble drugs. For example, the antibiotic gentamicin sulfate, a highly water-soluble drugs, was solubilized in aqueous phase followed by dispersing into organic phase consisting of PLA, polycaprolactone (PCL), and poly­( d , l -lactic- co -glycolic acid) (PLGA) with the surfactant SPAN80. The prepared mats showed a considerable sudden release in the first 8 h and then gradually released the remaining drugs during the next 4–6 days .…”
Section: Electrospinning Of Pla Nanofibersmentioning
confidence: 99%
“…Regardless of the above‐mentioned cases, these nanofibers have a heterogeneous drug distribution, and SDR is still the most considered application case for medicated core–shell nanofibers in drug delivery field. Core–shell nanostructures can also be created using a single‐fluid emulsion process to provide the desired SDR profiles (Liu et al, 2020).…”
Section: Typical Electrospun Multi‐layer Nanostructures and Their Typ...mentioning
confidence: 99%