A biodegradable magnesium surgical staple for colonic anastomosis: In vitro and in vivo evaluation

Structure-function integrated biodegradable Mg/polymer composites: Design, manufacturing, properties, and biomedical applications

“…(ii) After MAO treatment, the Mg surface is covered by a dense layer of MgO ceramic, which inhibits the penetration of corrosive ions in the degradation medium and reduces its self-corrosion current density [ 79 ]. (iii) When PLA is further coated to Mg-MAO, it acts as a barrier to block water and corrosive ions from entering the interior of BMPC and reacting with Mg. With this dual barrier effect, both the total amount and the hydrogen gas release rate from BMPC are effectively controlled, achieving a balance with the tissue's rate of hydrogen gas absorption [ 80 ]. In short, the study of controllable degradation of BMPC has always been a focus and a challenging issue.…”

“…For example, in the gastrointestinal environment, an intestinal surgical staple needs to maintain the anastomosis state (strength) for at least 7 days, but Mg corrodes too quickly in the gastrointestinal environment. Therefore, researchers constructed Mg-MAO/PLLA composite anastomosis nails to meet the time scale compatibility [ 80 ]. For soft tissues such as urethral tissue, researchers tend to use the faster degrading PLGA50:50, with the addition of a moderate amount of Mg (less than 9 wt%) to allow it to degrade completely within 2–3 months, meeting the time scale compatibility for soft tissue repair [ 88 ].…”

An overview of magnesium-based implants in orthopaedics and a prospect of its application in spine fusion

“…These Mg wires were further processed into hemostatic clips or stents and were widely used in the fields of cardiac surgery [ 276 ] ( Fig. 11 A), general surgery [ [277] , [278] , [279] ] ( Fig. 11 E–G), neurosurgery [ 280 ] ( Fig.…”

Porous Mg–Zn–Ca scaffolds for bone repair: a study on microstructure, mechanical properties and in vitro degradation behavior

“…Mg and its alloys have been paid much attention owing to their suitable mechanical properties (such as elastic modulus and density close to human bone [ 12 ]), favorable biodegradability [ 13 , 14 ], and good biocompatibility [ 15 ]. Besides, Mg is one of the macro elements in the human body, playing an osteoinductive and osteoconductive role in the growth of bone tissue and the healing of bone fractures [ 16 ].…”