A bioinformatic investigation of proteasome and autophagy expression in the central nervous system

Watanabe, Yasuhiro; Takeda, Haruka; Honda, Naoto; Hanajima, Ritsuko

doi:10.1016/j.heliyon.2023.e18188

Heliyon

2023

DOI: 10.1016/j.heliyon.2023.e18188

|View full text |Cite

A bioinformatic investigation of proteasome and autophagy expression in the central nervous system

Yasuhiro Watanabe¹,

Haruka Takeda²,

Naoto Honda³

et al.

Help me understand this report

View preprint versions

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Book1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Nervous System, Neurons, and Metabolism

Konukoglu

2024

Alzheimer’s Disease From Molecular Mechanisms to Clinical Practices

View full text Add to dashboard Cite

Alzheimer’s disease (AD) is a neurodegenerative disorder that leads to cognitive decline and is the most common form of dementia in the elderly. Neurons, as the primary cells of the central nervous system, are fundamental to brain function. Understanding their structure and functions is crucial for grasping AD mechanisms. Neurons consist of three main components: the cell body (soma), dendrites, and axon. The cell body is the metabolic center of the neuron, containing the nucleus and organelles. Dendrites receive signals from other neurons, while axons transmit these signals to other neurons or muscle cells. Synaptic terminals at the end of axons release neurotransmitters, facilitating communication between neurons. Neuronal metabolic activities include energy production, protein synthesis, and intracellular transport. Mitochondria play a crucial role in energy production, and mitochondrial dysfunction is a significant factor in AD. Reduced energy production adversely affects neuronal functionality and survival. In conclusion, the structure and metabolic processes of neurons play a critical role in the pathogenesis of AD. The disruption of neuronal structures and functions leads to the clinical manifestations of AD. Therefore, protecting neurons and supporting their functions are crucial targets in the treatment of AD.The initial part of the book provides an essential understanding of neuron biology, focusing on their functions and energy metabolism. The section examines the structural characteristics of neurons and their roles in neural communication. The chapter emphasizes efficient metabolic pathways, detailing glycolysis, oxidative phosphorylation, and ATP generation, and highlights the critical dependence of neuronal function on a continuous and sufficient energy supply.

show abstract

Nervous System, Neurons, and Metabolism

Konukoglu

2024

Alzheimer’s Disease From Molecular Mechanisms to Clinical Practices

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

A bioinformatic investigation of proteasome and autophagy expression in the central nervous system

Cited by 1 publication

References 48 publications

Nervous System, Neurons, and Metabolism

Nervous System, Neurons, and Metabolism

Contact Info

Product

Resources

About