A bioink blend for rotary 3D bioprinting tissue engineered small-diameter vascular constructs

Freeman, Sebastian; Ramos, Rafael; Chando, Paul; Zhou, Luxi; Reeser, Kyle; Jin, Sha; Soman, Pranav; Ye, Kaiming

doi:10.1016/j.actbio.2019.06.052

Cited by 114 publications

(82 citation statements)

References 68 publications

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“…The coated-PDA layer enhanced the ability of the hydrophilicity; it also remarkably increased the vascular cell proliferation and angiogenic differentiation during in vivo/in vitro. Sebastian Freeman et al developed fibrin-based vascular constructs using rod supporting bioprinting [135]. The printable bioink consists of the fibrinogen with gelatin to achieve the desired shear-thinning property for self-standing.…”

Section: Blood Vesselmentioning

confidence: 99%

3D Bioprinting Strategies for the Regeneration of Functional Tubular Tissues and Organs

et al. 2020

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It is difficult to fabricate tubular-shaped tissues and organs (e.g., trachea, blood vessel, and esophagus tissue) with traditional biofabrication techniques (e.g., electrospinning, cell-sheet engineering, and mold-casting) because these have complicated multiple processes. In addition, the tubular-shaped tissues and organs have their own design with target-specific mechanical and biological properties. Therefore, the customized geometrical and physiological environment is required as one of the most critical factors for functional tissue regeneration. 3D bioprinting technology has been receiving attention for the fabrication of patient-tailored and complex-shaped free-form architecture with high reproducibility and versatility. Printable biocomposite inks that can facilitate to build tissue constructs with polymeric frameworks and biochemical microenvironmental cues are also being actively developed for the reconstruction of functional tissue. In this review, we delineated the state-of-the-art of 3D bioprinting techniques specifically for tubular tissue and organ regeneration. In addition, this review described biocomposite inks, such as natural and synthetic polymers. Several described engineering approaches using 3D bioprinting techniques and biocomposite inks may offer beneficial characteristics for the physiological mimicry of human tubular tissues and organs.

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Section: Blood Vesselmentioning

confidence: 99%

3D Bioprinting Strategies for the Regeneration of Functional Tubular Tissues and Organs

et al. 2020

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“…Fibrin gel promotes deposition of collagen in neonatal rat aortic smooth muscle cells (SMCs), but its low viscosity makes it inappropriate for 3D bioprinting. 42,43 Collagen has been used as bioink for 3D bioprinting. 44 However, long gelation time limits the application of collagen in 3D bioprinting.…”

Section: D Printing Of Tevgsmentioning

confidence: 99%

“…46,47 The hydrolyzed derivative of collagen, gelatin, has been used in blend with other biomaterials as various bioinks establishing TEVGs. 43 Alginate can be used as a good printable biomaterial, but lacks proper cell-attaching sites. 48 These biomaterials require mixing with other biomaterials to improve their inherent properties for 3D bioprinting.…”

Section: D Printing Of Tevgsmentioning

confidence: 99%

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Vascular Tissue Engineering: Advanced Techniques and Gene Editing in Stem Cells for Graft Generation

Chen

Ugwu

Li³

et al. 2021

Tissue Engineering Part B: Reviews

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The common occurrence of cardiovascular diseases and the lack of proper autologous tissues prompt and promote the pressing development of tissue-engineered vascular grafts. Current progress on scaffold production, genetically modified cells and use of nanotechnology-based monitoring has considerably improved the long-term patency of engineered tissue grafts. However, challenges abound in the autologous materials and manipulation of genes and cells for tissue engineering. This review overviews current development in tissue-engineered vascular grafts and discusses recent improvements in scaffolding techniques as well as the efficiency of gene-editing tools and their ability to fill the existing gaps in stem-cell and regenerative therapies. Current advances in 3D-printing approaches for fabrication of engineered tissues are also reviewed together with specific biomaterials for vascular tissues. In addition, the natural and synthetic polymers that hold increasing significance for vascular tissue engineering are highlighted. Both animal models and nanotechnology-based monitoring are proposed for pre-clinical evaluation of engineered grafts in view of their historical significance in tissue engineering. The ultimate success of tissue regeneration, which is yet to be fully realized, depends on the optimal performance of culture systems, biomaterial constructs and stem cells in a suitable artificial physiological environment.

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“…Hydrogels based on gelatine and methacrylamide have been found appropriate to simulate liver tissue, a hepatocyte cell survival rate of 97% being found [43]. It can be deduced that hybrid composite materials with natural and synthetic polymers are gaining relevance to develop biomimetic scaffolds [44][45][46].…”

Section: Biomimetic Hybrid Systems Based On Natural Polymers For Tissmentioning

confidence: 99%

Biomimetic Hybrid Systems for Tissue Engineering

2020

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Tissue engineering approaches appear nowadays highly promising for the regeneration of injured/diseased tissues. Biomimetic scaffolds are continuously been developed to act as structural support for cell growth and proliferation as well as for the delivery of cells able to be differentiated, and also of bioactive molecules like growth factors and even signaling cues. The current research concerns materials employed to develop biological scaffolds with improved features as well as complex preparation techniques. In this work, hybrid systems based on natural polymers are discussed and the efforts focused to provide new polymers able to mimic proteins and DNA are extensively explained. Progress on the scaffold fabrication technique is mentioned, those processes based on solution and melt electrospinning or even on their combination being mainly discussed. Selection of the appropriate hybrid technology becomes vital to get optimal architecture to reasonably accomplish the final applications. Representative examples of the recent possibilities on tissue regeneration are finally given.

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A bioink blend for rotary 3D bioprinting tissue engineered small-diameter vascular constructs

Cited by 114 publications

References 68 publications

3D Bioprinting Strategies for the Regeneration of Functional Tubular Tissues and Organs

3D Bioprinting Strategies for the Regeneration of Functional Tubular Tissues and Organs

Vascular Tissue Engineering: Advanced Techniques and Gene Editing in Stem Cells for Graft Generation

Biomimetic Hybrid Systems for Tissue Engineering

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