A bioinspired elastin-based protein for a cytocompatible underwater adhesive

Brennan, M. Jane; Kilbride, B; Wilker, Jonathan J.; Liu, Julie C.

doi:10.1016/j.biomaterials.2017.01.034

Cited by 130 publications

(133 citation statements)

References 66 publications

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“…Its applications are expanding because of its excellent adhesion properties and adaptability to a variety of substrates . However, still a challenge is the fact that PU's bonding is achieved in the presence of water; this results from the presence of interstitial water and the decomposition of PU's matrix by the permeation of water molecules . Because of the limitations of traditional PU adhesion, there are significant advantages to developing PU adhesives that work in aqueous environments, especially in engineering and surgery fields.…”

Section: Introductionmentioning

confidence: 99%

Underwater polyurethane adhesive with enhanced cohesion by postcrosslinking of glycerol monomethacrylate

Xie

Liu

et al. 2018

J of Applied Polymer Sci

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Polyurethane (PU) has been widely used as a glue in various areas. However, adhesion in the presence of water is greatly impeded and results in most synthetic adhesive failure. In this study, we designed and synthesized a novel PU construction; underwater PU adhesives were created by the incorporation of synthetic glycerol monomethacrylate (GMA). Furthermore, the urethane structure helped the adhesive eliminate the interfacial water barrier through interactions that were stronger than hydrogen bonding, and GMA as a crosslinking agent was used to generate post-covalent-crosslinking networks through radical polymerization. This enhanced the cohesion so the diffusion of water molecules could be overcome. Fourier transform infrared spectroscopy, thermogravimetric analysis, underwater adhesion measurements, and tensile tests were used to characterize the chemical and mechanical properties of the as-obtained adhesive. This led to an adhesive with a better mechanical strength and interfacial adhesion in water, and the results show that the mechanical properties (tensile strength, Young's modulus, and tensile elongation) of the GMA-PU adhesive were higher than those of the pure PU. As for the 4% GMA, the tensile strength was enhanced by 24.3% and the elongation was enhanced by 125.23% over those of the pure PU. This confirmed that the incorporation of GMA into the PU matrix indeed induced increasing cohesion, and the sample's adhesive strength was 21.19 6 3.9 MPa; this indicated a superior adhesive strength over that of the pure PU. In addition, we can foresee that underwater adhesion will play an important role in prospective surgery and engineering areas. V C 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46579.

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Section: Introductionmentioning

confidence: 99%

Underwater polyurethane adhesive with enhanced cohesion by postcrosslinking of glycerol monomethacrylate

Xie

Liu

et al. 2018

J of Applied Polymer Sci

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Section: Protein‐based Adhesivesmentioning

confidence: 99%

“…Heating over a lower critical solution temperature (LCST), ELPs possess their tunable phase transition behavior from the entropically favored rearrangement of water to form coacervates. Accordingly, Liu and co‐workers designed mussel‐inspired adhesives by enzymatically converting tyrosine‐rich residues of ELYs (constructed from ELP) into DOPA (Figure B) . In their study, ELYs with a repeated amino acid sequence Val–Pro–Gly–Xaa–Gly were cloned using standard techniques.…”

Section: Protein‐based Adhesivesmentioning

confidence: 99%

Fabrication and Mechanical Properties of Engineered Protein‐Based Adhesives and Fibers

Sun

et al. 2019

Advanced Materials

124

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Protein-based structural biomaterials are of great interest for various applications because the sequence flexibility within the proteins may result in their improved mechanical and structural integrity and tunability. As the two representative examples, protein-based adhesives and fibers have attracted tremendous attention. The typical protein adhesives, which are secreted by mussels, sandcastle worms, barnacles, and caddisfly larvae, exhibit robust underwater adhesion performance. In order to mimic the adhesion performance of these marine organisms, two main biological adhesives are presented, including genetically engineered protein-based adhesives and biomimetic chemically synthetized adhesives. Moreover, various protein-based fibers inspired by spider and silkworm proteins, collagen, elastin, and resilin are studied extensively. The achievements in synthesis and fabrication of structural biomaterials by DNA recombinant technology and chemical regeneration certainly will accelerate the explorations and applications of protein-based adhesives and fibers in wound healing, tissue regeneration, drug delivery, biosensors, and other high-tech applications. However, the mechanical properties of the biological structural materials still do not match those of natural systems. More efforts need to be devoted to the study of the interplay of the protein structure, cohesion and adhesion effects, fiber processing, and mechanical performance.

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“…[9] A bioinspired hydrogel adhesive with dissipate matrix and adhesive surface was successfully designed for different wet and soft surface. [17][18][19] However, most works only focused on the adhesion behavior in air and/or water, the technology of strong adhesion and acrylate adenine were utilized to fabricate adhesive gels via the radical polymerization in the mixed solvents of water and DMSO. [11] Moreover, underwater adhesion also achieved a prominent progress based on various nature-inspired strategies, including 3,4-dihydroxyphenyl-L-alanine (DOPA)-modified adhesives, [12,13] structure-inspired adhesives, [14][15][16] and biomimetic protein adhesives.…”

Section: Introductionmentioning

confidence: 99%

“…[11] Moreover, underwater adhesion also achieved a prominent progress based on various nature-inspired strategies, including 3,4-dihydroxyphenyl-L-alanine (DOPA)-modified adhesives, [12,13] structure-inspired adhesives, [14][15][16] and biomimetic protein adhesives. [17][18][19] However, most works only focused on the adhesion behavior in air and/or water, the technology of strong adhesion and acrylate adenine were utilized to fabricate adhesive gels via the radical polymerization in the mixed solvents of water and DMSO. The nucleobase-driven adhesive gels exhibited high mechanical strength with overcoming the problem of weak bulk cohesion for gel-based adhesives, comparing to the previous adhesive materials.…”

Section: Introductionmentioning

confidence: 99%

Tough Adhesion of Nucleobase‐Tackifed Gels in Diverse Solvents

Liu

Zhang

Duan

et al. 2019

Adv Funct Materials

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Adhesive gels have attracted increasing attention in biological medicine and industrial fields. However, it remains a huge challenge to achieve robust adhesion in various nonpolar and polar solvents. Herein, a tough nucleobasetackified adhesive gel is successfully fabricated and exhibits strong adhesion to various materials in diverse solvents, including hexane, chloroform, dimethyl sulfoxide, ethanol, and water (seawater, high salt, acid, and alkali aqueous solutions). The adhesive gels possess high toughness and excellent resist fatigue as well as impressive nonswelling behavior in water or oil. This tough gel-based adhesive holds great promise for various applications, such as battery adhesives, soft robots, wound dressing, wearable devices, and 3D printing in various environments. It is anticipated that this strategy will provide a novel route for fabricating the next generation of adhesive soft materials.

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A bioinspired elastin-based protein for a cytocompatible underwater adhesive

Cited by 130 publications

References 66 publications

Underwater polyurethane adhesive with enhanced cohesion by postcrosslinking of glycerol monomethacrylate

Underwater polyurethane adhesive with enhanced cohesion by postcrosslinking of glycerol monomethacrylate

Fabrication and Mechanical Properties of Engineered Protein‐Based Adhesives and Fibers

Tough Adhesion of Nucleobase‐Tackifed Gels in Diverse Solvents

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