2014
DOI: 10.1038/nbt.3020
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A bioinspired omniphobic surface coating on medical devices prevents thrombosis and biofouling

Abstract: ________________________________________________________________Countless lives have been saved by implantable medical devices (e.g., total artificial hearts, ventricular assist devices, pacemakers, cardioverterdefibrillators, and central lines) and extracorporeal devices that flow whole human blood outside the body through indwelling catheters and external circuits, during cardiopulmonary bypass (CPB), hemodialysis, and extracorporeal membrane oxygenation (ECMO) 1,2 . However, the need to co-administer solubl… Show more

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Cited by 630 publications
(666 citation statements)
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“…The characteristics of liquid-infused coatings may provide a potential solution to mitigate the performance concerns in endoscopes, especially because methodologies have been developed to create transparent coatings with efficient liquid repellency (16,(20)(21)(22)27). Here, we design and explore the function of a liquid-infused coating applied on a bronchoscope lens during clinically relevant procedures.…”
Section: Significancementioning
confidence: 99%
See 1 more Smart Citation
“…The characteristics of liquid-infused coatings may provide a potential solution to mitigate the performance concerns in endoscopes, especially because methodologies have been developed to create transparent coatings with efficient liquid repellency (16,(20)(21)(22)27). Here, we design and explore the function of a liquid-infused coating applied on a bronchoscope lens during clinically relevant procedures.…”
Section: Significancementioning
confidence: 99%
“…Recently, liquid-infused coatings, consisting of a porous structure infiltrated with a lubricant, have emerged as a new, alternative strategy for repellent materials (11,(13)(14)(15)(16)(17). The formation of a stable lubricant overlayer on the surface creates a dynamic slippery barrier that protects the underlying substrate from direct contact with polluted media, thus drastically lowering the adsorption of various serious contaminants including bacteria (18,19) and proteins (20)(21)(22). This new, non-fouling material can be designed to perform under flow (23,24), provide enhanced damage tolerance (15,16) and selfhealing capabilities (11), or be integrated with a vascularized network that secretes the lubricant to repair the interface (25,26).…”
Section: Significancementioning
confidence: 99%
“…As a result, micro-/nanofabrication techniques have been employed to develop bio-inspired topographical features. [1][2][3][4][5] Here, we employed sand dollars (Dendraster excentricus) as robust templates for creating superhydrophobic polydimethylsiloxane (PDMS). Sand dollars are sea urchins (echinoderms) from the order Clypeasteroida.…”
Section: Introductionmentioning
confidence: 99%
“…For example, some hydrogels repel proteins electrostatically, which avoids immune reactions or the biosurface becoming fouled 6 . Repellent coatings on medical devices such as catheters can be based on slippery, liquid-infused, porous surfaces (SLIPS) to prevent thrombosis 7 .…”
Section: Advanced Polymersmentioning
confidence: 99%