A biomimetic cascade nanoreactor for tumor targeted starvation therapy-amplified chemotherapy

Cheng, Hong; Jiang, Xueyan; Zheng, Rongrong; Zuo, Shengjia; Zhao, Lin‐Ping; Fan, Guijuan; Xie, Bo‐Ru; Yu, Xiyong; Li, Shiying; Zhang, Xian‐Zheng

doi:10.1016/j.biomaterials.2019.01.003

Cited by 136 publications

(67 citation statements)

References 65 publications

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“…Photodynamic therapy produces singlet oxygen to strengthen the efficacy of paclitaxel-based chemotherapy 18 . Among others, the combination of starving therapy and chemotherapy is promising for realizing an optimal therapeutic effect due to the different mechanism of the two modalities 19 , 20 .…”

Section: Introductionmentioning

confidence: 99%

Self-accelerating H₂O₂-responsive Plasmonic Nanovesicles for Synergistic Chemo/starving therapy of Tumors

Tang

et al. 2020

Theranostics

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Rationale: Nanoscale vehicles responsive to abnormal variation in tumor environment are promising for use in targeted delivery of therapeutic drugs specifically to tumor sites. Herein, we report the design and fabrication of self-accelerating H 2 O 2 -responsive plasmonic gold nanovesicles (GVs) encapsulated with tirapazamine (TPZ) and glucose oxidase (GOx) for synergistic chemo/starving therapy of cancers. Methods: Gold nanoparticles were modified with H 2 O 2 -responsive amphiphilic block copolymer PEG 45 - b -PABE 330 by ligand exchange. The TPZ and GOx loaded GVs (TG-GVs) were prepared through the self-assembly of PEG 45 - b -PABE 330 -grafted nanoparticles together with TPZ and GOx by solvent displacement method. Results: In response to H 2 O 2 in tumor, the TG-GVs dissociate to release the payloads that are, otherwise, retained inside the vesicles for days without noticeable leakage. The released GOx enzymes catalyze the oxidation of glucose by oxygen in the tumor tissue to enhance the degree of hypoxia that subsequently triggers the reduction of hypoxia-activated pro-drug TPZ into highly toxic free radicals. The H 2 O 2 generated in the GOx-catalyzed reaction also accelerate the dissociation of vesicles and hence the release rate of the cargoes in tumors. The drug-loaded GVs exhibit superior tumor inhibition efficacy in 4T1 tumor-bearing mice owing to the synergistic effect of chemo/starvation therapy, in addition to their use as contrast agents for computed tomography imaging of tumors. Conclusion: This nanoplatform may find application in managing tumors deeply trapped in viscera or other important tissues that are not compatible with external stimulus (e.g. light).

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Section: Introductionmentioning

confidence: 99%

Self-accelerating H₂O₂-responsive Plasmonic Nanovesicles for Synergistic Chemo/starving therapy of Tumors

Tang

et al. 2020

Theranostics

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“…The collaborative starving and suffocating effects would result in excellent antitumor efficacy. Zhang and other researchers have also demonstrated this enhanced cancer therapy via the combination of cancer starvation therapy with chemotherapy, immunotherapy, and PDT 111 …”

Section: Exploiting Tumor Hypoxiamentioning

confidence: 86%

Application of nanotechnology for enhancing photodynamic therapy via ameliorating, neglecting, or exploiting tumor hypoxia

Pan

et al. 2020

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Photodynamic therapy (PDT), an oxygen‐dependent modality, has been clinically approved and is considered a promising approach for cancer treatment. However, PDT shows noticeable limits due to the hypoxic nature of most solid tumor microenvironments. In recent years, various strategies have been developed to overcome tumor hypoxia either via oxygen‐replenishing approaches or via diminishing oxygen dependence. Both of these approaches have shown promise in reversing hypoxia‐relevant PDT resistance and thus improve antitumor efficacy. However, the low oxygen level at the tumor site is also an opportunity for the development of new therapeutic modalities, such as hypoxia‐activated chemotherapy, hypoxia‐inducible drug release, and starvation therapy. Therefore, a combination of these therapeutic modalities with PDT could promote their synergetic efficacy. Herein, we present an overview of the recent trend in the modulation and utilization of tumor hypoxia via nanomedicine‐based strategies, followed by a summary of the design and mechanisms of these nanosystems to improve PDT. Finally, current challenges and future perspectives for how PDT can achieve more extensive clinical applications for cancer therapy are discussed.

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“…Also, the amplification of chemotherapy via cancer-targeted starvation therapy by reducing glucose availability to cancer cells has recently been reported. Doxorubicin-loaded metal organic frameworks coated with glucose oxidase (GOx)-inserted lung CCM (4T1 cell) displayed glycolytic activity and functioned as a cascade nanoreactor, showing enhanced intracellular doxorubicin release and GOx-mediated glucose depletion [9]. The cancer-homing features conveyed by CCMs can also benefit the intracellular uptake of photosensitizers, and therefore expand their ROS-mediated cytotoxicity to cancer cells upon light irradiation.…”

Section: Pharmaceutical Applications Of Ccmsmentioning

confidence: 99%

Biomimetic cancer cell membrane-coated nanosystems as next-generation cancer therapies

Pereira-Silva

Santos

Conde

et al. 2020

Expert Opinion on Drug Delivery

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A biomimetic cascade nanoreactor for tumor targeted starvation therapy-amplified chemotherapy

Cited by 136 publications

References 65 publications

Self-accelerating H₂O₂-responsive Plasmonic Nanovesicles for Synergistic Chemo/starving therapy of Tumors

Self-accelerating H₂O₂-responsive Plasmonic Nanovesicles for Synergistic Chemo/starving therapy of Tumors

Application of nanotechnology for enhancing photodynamic therapy via ameliorating, neglecting, or exploiting tumor hypoxia

Biomimetic cancer cell membrane-coated nanosystems as next-generation cancer therapies

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A biomimetic cascade nanoreactor for tumor targeted starvation therapy-amplified chemotherapy

Cited by 136 publications

References 65 publications

Self-accelerating H2O2-responsive Plasmonic Nanovesicles for Synergistic Chemo/starving therapy of Tumors

Self-accelerating H2O2-responsive Plasmonic Nanovesicles for Synergistic Chemo/starving therapy of Tumors

Application of nanotechnology for enhancing photodynamic therapy via ameliorating, neglecting, or exploiting tumor hypoxia

Biomimetic cancer cell membrane-coated nanosystems as next-generation cancer therapies

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Product

Resources

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Self-accelerating H₂O₂-responsive Plasmonic Nanovesicles for Synergistic Chemo/starving therapy of Tumors

Self-accelerating H₂O₂-responsive Plasmonic Nanovesicles for Synergistic Chemo/starving therapy of Tumors