A biomimetic hyperbranched poly(amino ester)-based nanocomposite as a tunable bone adhesive for sternal closure

Zhang, Hong; Bré, Lígia Pereira; Zhao, Tianyu; Newland, Ben; Costa, Mark Da; Wang, Wenxian

doi:10.1039/c4tb00155a

Cited by 69 publications

(83 citation statements)

References 30 publications

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“…Inspired by the adhesion strategy of marine mussels, a new family of biomimetic, mussel-inspired adhesives has become an area of intense research. Mussel-inspired polymers are synthesized from catechol-containing amino acids such as L-3,4-dihydroxy -phenylalanine (L-DOPA), typically derived from various mussel adhesion proteins, known to contribute to the strong wet adhesion strength of marine mussels to non-specific surfaces [5, 9–13]. Among those polymers, injectable, citrate-based, mussel-inspired bioadhesives (iCs) [11] and antimicrobial iCs [12] developed in our group have been acknowledged for their cost-effective and convenient syntheses along with vastly improved wet adhesion strength as compared to that of fibrin glue.…”

Section: Introductionmentioning

confidence: 99%

“…However, mussel-inspired polymers including iCs commonly suffer from insufficient cohesive strength under wet conditions, as polymers can easily detach from adhered surfaces by deformation or stretching [10–13]. Strong wet mechanical strength is particularly vital for in vivo applications, hence our goal was to further chemically modify iCs to optimize this property.…”

Section: Introductionmentioning

confidence: 99%

“…Strong wet mechanical strength is particularly vital for in vivo applications, hence our goal was to further chemically modify iCs to optimize this property. The catechol groups in previously reported formulations of iCs participate in the formation of crosslinked polymer networks, reducing the number of available catechol groups that can chemically react with wet tissues [10–13]. Moreover, the rapid degradation rate of iCs remains a significant challenge as it may lead to undesirable early structural collapse and failure of wound closure.…”

Section: Introductionmentioning

confidence: 99%

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Click chemistry improved wet adhesion strength of mussel-inspired citrate-based antimicrobial bioadhesives

et al. 2017

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For the first time, a convenient copper-catalyzed azide-alkyne cycloaddition (CuAAC, click chemistry) was successfully introduced into injectable citrate-based mussel-inspired bioadhesives (iCMBAs, iCs) to improve both cohesive and wet adhesive strengths and elongate the degradation time, providing numerous advantages in surgical applications. The major challenge to developing such an adhesive was the mutual inhibition effect between the oxidant used for crosslinking catechol groups and the Cu(II) reductant used for CuAAC, which was successfully minimized by adding a biocompatible buffering agent typically used in cell culture, 4-(2-hydroxyethyl) -1-piperazineethanesulfonic acid (HEPES), as a copper chelating agent. Among the investigated formulations, the highest adhesion strength achieved (223.11 ± 15.94 kPa) was around 13 times higher than that of a commercially available fibrin glue (15.4 ± 2.8 kPa). In addition, dual-crosslinked (i.e. click crosslinking and mussel-inspired crosslinking) iCMBAs still preserved considerable antibacterial and antifungal capabilities that are beneficial for the bioadhesives used as hemostatic adhesives or sealants for wound management.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Click chemistry improved wet adhesion strength of mussel-inspired citrate-based antimicrobial bioadhesives

et al. 2017

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“…Recently, host-guest chemistry strategy was reportedly employed to prepare underwater adhesives; however, the substrate surface needs to be modified in advance. However, several problems, such as the complexity of administration, release of harmful organic solvents, [18,19] long-term curing, [2] need for oxidant addition, [20,21] and low adhesion strength, [18,22] may hamper the actual applications of these bioinspired adhesives. [13,14] In nature, many organisms, such as mussels, barnacles, and castle worms, have evolved an unparalleled mechanism to perfectly tackle the underwater adhesion problem.…”

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confidence: 99%

Water‐Triggered Hyperbranched Polymer Universal Adhesives: From Strong Underwater Adhesion to Rapid Sealing Hemostasis

et al. 2019

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is greatly decreased or even eliminated. For instance, the widely used cyanoacrylate adhesives exhibit strong adhesion in air, but when applied in water environment, they are hardened quickly to form a layer of stiff plastics, eventually resulting in the loss of adhesion. [9] The commercially available epoxy resins [10] and polyurethanes [11] are reported to demonstrate strong underwater adhesion, but long time of curing is usually required. Recently, host-guest chemistry strategy was reportedly employed to prepare underwater adhesives; however, the substrate surface needs to be modified in advance. [5,12] In addition, electrostatic and hydrophobic interactions were also proved to contribute to enhanced underwater adhesion, but the adhesion strength was relatively poor. [13,14] In nature, many organisms, such as mussels, barnacles, and castle worms, have evolved an unparalleled mechanism to perfectly tackle the underwater adhesion problem. [15][16][17] The finding of universality of catechol chemistry for wet adhesion has provided a valuable biomimetic source to develop diverse adhesives for use in aqueous environments. However, several problems, such as the complexity of administration, release of harmful organic solvents, [18,19] long-term curing, [2] need for oxidant addition, [20,21] and low adhesion strength, [18,22] may hamper the actual applications of these bioinspired adhesives. Although numerous dopamine-based adhesives have been reported and shown to bond various material surfaces, strong adhesion in water and particularly blood environment, remains nonexistent so far.Increasing studies on bioadhesives secreted by molluscs and insects have suggested that liquid coacervation plays a critical role in achieving underwater adhesion. [13] In this process, phase separation and concurrently increased hydrophobicity induced by coacervation can dispel the hydrated water on the interface, leading to much enhanced interaction of adhesive groups with the adherent and thus stable underwater adhesion. Up to date, several complex coacervate adhesives with linear structure have been reported, but the occurrence of those coacervations in water needs external triggers, such as temperature, [13] pH, [20,23] and iron strength. [24] Compared to linear counterparts, hyperbranched polymer (HBP) has a unique highly branched Despite recent advance in bioinspired adhesives, achieving strong adhesion and sealing hemostasis in aqueous and blood environments is challenging. A hyperbranched polymer (HBP) with a hydrophobic backbone and hydrophilic adhesive catechol side branches is designed and synthesized based on Michael addition reaction of multi-vinyl monomers with dopamine.It is demonstrated that upon contacting water, the hydrophobic chains selfaggregate to form coacervates quickly, displacing water molecules on the adherent surface to trigger increased exposure of catechol groups and thus rapidly strong adhesion to diverse materials from low surface energy to high energy in various environments, such as deionized water, sea ...

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“…[1][2][3][4][5][6][7][8][9] In view of the types of driving forces for crosslinking, hydrogels can be divided into two major categories: synthetic hydrogels and supramolecular hydrogels. 11,12 However, such hydrogels are often brittle, at times opaque and without the ability to self-heal when the cross-linked network is broken, thus greatly limiting their application in various biomedical fields. Since the first example of synthetic hydrogels was reported by Wichterle and Lim in 1960, 10 great interest for a wide range of biomedical applications from drug delivery to tissue engineering owing to their hydrophilic character and potential to be biocompatible.…”

Section: Introductionmentioning

confidence: 99%

Supramolecular hydrogels: synthesis, properties and their biomedical applications

et al. 2015

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As a novel class of three-dimensional (3D) hydrophilic cross-linked polymers, supramolecular hydrogels not only display unique physicochemical properties (e.g., water-retention ability, drug loading capacity, biodegradability and biocompatibility, biostability) as well as specific functionalities (e.g., optoelectronic properties, bioactivity, self-healing ability, shape memory ability), but also have the capability to undergo reversible gel-sol transition in response to various environmental stimuli inherent to the noncovalent cross-linkages, thereby showing great potential as promising biomaterial scaffolds for diagnosis and therapy. In this Review, we summarized the recent progress in the design and synthesis of supramolecular hydrogels through specific, directional noncovalent interactions, with particular emphasis on the structure-property relationship, as well as their wide-ranging applications in disease diagnosis and therapy including bioimaging, biodetection, therapeutic delivery, and tissue engineering. We believe that these current achievements in supramolecular hydrogels will greatly stimulate new ideas and inspire persistent efforts in this hot topic area in future.

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A biomimetic hyperbranched poly(amino ester)-based nanocomposite as a tunable bone adhesive for sternal closure

Cited by 69 publications

References 30 publications

Click chemistry improved wet adhesion strength of mussel-inspired citrate-based antimicrobial bioadhesives

Click chemistry improved wet adhesion strength of mussel-inspired citrate-based antimicrobial bioadhesives

Water‐Triggered Hyperbranched Polymer Universal Adhesives: From Strong Underwater Adhesion to Rapid Sealing Hemostasis

Supramolecular hydrogels: synthesis, properties and their biomedical applications

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