A biomimetic metal–organic framework with cuboid inner cavities for enantioselective separation

Abstract

A chiral metal-organic framework with accessible binding pockets and multiple recognition sites is constructed from a tricarboxylate ligand derived from phenylalanine. The CMOF features a rare structure with cavities gated...

Polypeptide-inspired supramolecular assemblies for enantioselective sorption of chiral molecules

“…Our previous work also suggested that the presence of more accessible phenylalanine residues in the larger pores of chiral materials that serve as recognition sites helps improve the enantioselectivity towards small chiral molecules. 39 Herein, we highlight the significance of amino acid residues in the supramolecular assemblies to regulate the chiral microenvironment for the highly enantioselective capture.…”

“…The uncoordinated and flexible phenylalanine residues tune the open cavities and chiral environment within the micropores to achieve enantioselective and size-dependent recognition and adsorption. 39 Unfortunately, the chiral recognition sites in the 3D frameworks failed to be subtly tuned by other amino acids under identical synthetic conditions. Inspired by the intricate self-assembly of polypeptide chains with plentiful chiral sites, we herein leveraged amino acid-derived ligands with a C 2 symmetry to construct one-dimensional coordination polymers (Scheme 1), which can be interconnected to generate novel supramolecular assemblies with unique chiral cavities and multiple functional sites through abundant non-covalent interactions.…”

High-Enantioselectivity Adsorption Separation of Racemic Mandelic Acid and Methyl Mandelate by Robust Chiral UiO-68-Type Zr-MOFs

“…However, they often suffer from operational complexity, high price, low efficiency, and instability. Adsorption separation was found to be a simple, rapid, efficient, and byproduct-free process that is environmentally friendly and does not release any toxic substances. − Therefore, the development of chiral adsorption materials with excellent enantioselectivity and competitiveness is necessary to achieve ideal and efficient enantioseparation. Homochiral metal–organic frameworks (HMOFs) are an emerging class of chiral porous materials that have aroused considerable interest due to their unique chirality and well-defined intrinsic cavities. − Very importantly, HMOF materials can provide pivotal confined chiral spaces and preset chiral recognition sites where stereospecific interactions for different enantiomers occur, which is essential for chiral recognition and separation.…”