A biomimetic well-aligned silk fibroin/calcium phosphate composite by electrospinning and in-situ mineralization

Silk Protein-Mediated Biomineralization: From Bioinspired Strategies and Advanced Functions to Biomedical Applications

“…The integration of inorganic minerals with silk proteins imparts new biological, physical, and chemical functionalities to silk proteins, significantly expanding the scope of applications for these materials. These unique properties expand the scope of applications for SBBMs, highlighting their potential as versatile and functional materials in a variety of fields. ,, First, the benefits of biomineralization are evident in the enhancement of mechanical properties. In living organisms, skin tissue lacks high mechanical strength, whereas bone tissue exhibits ultrahigh mechanical strength, largely due to the presence of HA and the hierarchically ordered structure of its components .…”

“…Silk protein is a naturally occurring, animal-derived protein, and it is a continuous, long fiber secreted by spiders or mature silkworms during their life activities. − In mulberry silkworm cocoons, the protein content is approximately 97%, consisting of silk fibroin (SF) and silk sericin (SS). Numerous excellent research studies and reviews have delved into the structural characteristics of silk proteins and their applications in various fields, including tissue engineering, − drug delivery systems, smart wearables, sensing, and others. , As shown in Figure , both silk proteins and collagen are structural proteins, that contain significant amounts of polar amino acids. Additionally, both proteins are regularly oriented fibrous structures that are formed by the hierarchical assembly of nanofibrils.…”