A biomineralized bi-functional hybrid nanoflower to effectively combat bacteria<i>via</i>a glucose-powered cascade catalytic reaction

Tang, Qiaorong; Shi, Lu; Yang, Bing; Liu, Wei; Li, Baoxin; Jin, Yan

doi:10.1039/d2tb02704f

Cited by 7 publications

(2 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, diabetic patients have a risk of community-acquired bacterial infections, like streptococcal infection, due to a high glucose level. [59] Tang et al [60] developed a bi-functional hybrid nanoflower to combat bacterial infections in response to glucose. This nanoflower incorporated Cu 2+ coordination with guanosine monophosphate (GMP) and glucose oxidase (GOx).…”

Section: Responding To Disease Microenvironmentmentioning

confidence: 99%

See 1 more Smart Citation

Metal–Drug Coordination Nanoparticles and Hydrogels for Enhanced Delivery

Wong,

Nie,

Wong

et al. 2024

Advanced Materials

View full text Add to dashboard Cite

Drug delivery is a key component of nanomedicine, and conventional delivery relies on the adsorption or encapsulation of drug molecules to a nanomaterial. Many delivery vehicles contain metal ions such as metal‐organic frameworks, metal oxides, transition metal dichalcogenides, MXene and noble metal nanoparticles. These materials have a high metal content and pose potential long‐term toxicity concerns leading to difficulties for clinical approval. In this review, we summarize recent developments in the use of drug molecules as ligands for metal coordination forming various nanomaterials and soft materials. In these cases, the drug‐to‐metal ratio is much higher than conventional adsorption‐based strategies. The drug molecules are divided into small‐molecule drugs, nucleic acids, and proteins. The formed hybrid materials mainly include nanoparticles and hydrogels, upon which targeting ligands can be grafted to improve efficacy and further decrease toxicity. The application of these materials for addressing cancer, viral infection, bacterial infection inflammatory bowel disease, and bone diseases is reviewed. In the end, some future directions are discussed from fundamental research, materials science, and medicine.This article is protected by copyright. All rights reserved

show abstract

Section: Responding To Disease Microenvironmentmentioning

confidence: 99%

“…[ 59 ] Tang et al. [ 60 ] developed a bi‐functional hybrid nanoflower to combat bacterial infections in response to glucose. This nanoflower incorporated Cu 2+ coordination with guanosine monophosphate (GMP) and glucose oxidase (GOx).…”

Section: Advantages Of Metal–drug Coordinationmentioning

confidence: 99%