A Biophysical and Computational Study of Concanavalin A Immobilized Zinc Oxide Nanoparticles

Naeem, Aabgeena; Alam, Md. Tauqir; Khan, Taqi Ahmad; Husain, Qayyum

doi:10.2174/0929866524666170920114057

Cited by 3 publications

(2 citation statements)

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“…70 Hemagglutination or clustering of RBC is assessed by visual inspection or by dynamic light scattering. 68 These assays have been used to evaluate the hemagglutination capacity of NPs of chitosan, 68 gold, silver, 71 iron oxide, 70 zinc oxide, 72 and multiwalled carbon nanotubes (no hemagglutination). 70 These effects also seem to depend on the type, size, and surface moieties of the NPs.…”

Section: Hemolysis and Hemagglutinationmentioning

confidence: 99%

Design Considerations and Assays for Hemocompatibility of FDA-Approved Nanoparticles

Saha

Zhen

Erogbogbo

et al. 2019

Semin Thromb Hemost

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Nanoparticles have numerous biomedical applications including, but not limited to, targeted drug delivery, diagnostic imaging, sensors, and implants for a wide range of diseases including cancer, diabetes, heart disease, and tuberculosis. Although the mode of delivery of the nanoparticles depends on the application and the disease, the nanoparticles are often in immediate contact with the systemic circulation either because of intravenous administration or their ability to enter the bloodstream with relative ease or their longer survival time in circulation. Once in circulation, the nanoparticles may elicit unintended hemostatic and inflammatory responses, and hence the design of nanoparticles for therapeutic applications should take broad hemocompatibility concerns into consideration. In this review, we present the principles underlying the structural and functional design of various classes of nanoparticles that are currently approved by the US Food and Drug Administration, categorize these particles based on their interactions with cardiovascular tissues and ensuing adverse events, and also describe various in vitro assays that may be used evaluate their hemocompatibility.

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Section: Hemolysis and Hemagglutinationmentioning

confidence: 99%

Design Considerations and Assays for Hemocompatibility of FDA-Approved Nanoparticles

Saha

Zhen

Erogbogbo

et al. 2019

Semin Thromb Hemost

View full text Add to dashboard Cite

show abstract

“…Despite its enormous scope, one of nanotechnology's most significant benefits will be the development of innovative and successful medical treatments. Understanding the interactions of nanomaterials and biomolecules both in extracellular and inside the cells will open up new strategies for developing effective nanomedicines [9][10][11]. Nanomaterials are synthesized and modified accordingly nowadays for the gain of a variety of functions.…”

Section: Introductionmentioning

confidence: 99%

Investigating Chaperone like Activity of Green Silver Nanoparticles: Possible Implications in Drug Development

et al. 2022

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Protein aggregation and amyloidogenesis have been associated with several neurodegenerative disorders like Alzheimer’s, Parkinson’s etc. Unfortunately, there are still no proper drugs and no effective treatment available. Due to the unique properties of noble metallic nanoparticles, they have been used in diverse fields of biomedicine like drug designing, drug delivery, tumour targeting, bio-sensing, tissue engineering etc. Small-sized silver nanoparticles have been reported to have anti-biotic, anti-cancer and anti-viral activities apart from their cytotoxic effects. The current study was carried out in a carefully designed in-vitro to observe the anti-amyloidogenic and inhibitory effects of biologically synthesized green silver nanoparticles (B-AgNPs) on human serum albumin (HSA) aggregation taken as a model protein. We have used different biophysical assays like thioflavin T (ThT), 8-Anilino-1-naphthalene-sulphonic acid (ANS), Far-UV CD etc. to analyze protein aggregation and aggregation inhibition in vitro. It has been observed that the synthesized fluorescent B-AgNPs showed inhibitory effects on protein aggregation in a concentration-dependent manner reaching a plateau, after which the effect of aggregation inhibition was significantly declined. We also observed meaningful chaperone-like aggregation-inhibition activities of as-synthesized florescent B-AgNPs in astrocytes.

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Microwave-assisted one-pot multicomponent synthesis of steroidal pyrido[2,3-d]pyrimidines and their possible implications in drug development

et al. 2023

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A Biophysical and Computational Study of Concanavalin A Immobilized Zinc Oxide Nanoparticles

Cited by 3 publications

References 0 publications

Design Considerations and Assays for Hemocompatibility of FDA-Approved Nanoparticles

Design Considerations and Assays for Hemocompatibility of FDA-Approved Nanoparticles

Investigating Chaperone like Activity of Green Silver Nanoparticles: Possible Implications in Drug Development

Microwave-assisted one-pot multicomponent synthesis of steroidal pyrido[2,3-d]pyrimidines and their possible implications in drug development

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