A biophysical probe on the binding of 2-mercaptothioazoline to bovine hemoglobin

Zou, Lu‐Yi; Zhang, Xiaoyue; Shao, Mingying; Sun, Ruirui; Zhu, Yuting; Zou, Binbin; Huang, Zhenxing; Liu, He

doi:10.1007/s11356-018-3405-0

Cited by 4 publications

(1 citation statement)

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“…In addition, they are reported as butyrylcholinesterase and carboxylesterase inhibitors [14]. Motivated by the above-mentioned results, numerous design and synthesis efforts have been employed to develop new derivatives with more effective and safer therapeutic profiles [15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30]. Additionally, heterocycles based on a thiazoline-2-thione core may undergo several chemical reactions, including alkylation, oxidation, and cycloaddition, as a result of having two different nitrogenous and sulfurous groups [31,32,33,34,35,36,37].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, X-ray Analysis, Biological Evaluation and Molecular Docking Study of New Thiazoline Derivatives

et al. 2019

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A series of new thiazoline derivatives were synthesized. Structure analyses were accomplished employing 1H-NMR, 13C-NMR, X-ray and MS techniques. The in vitro antitumor activities were assessed against human hepatocellular carcinoma (HepG-2) and colorectal carcinoma (HCT-116) cell lines. The results revealed that the thiazolines 5b and 2c exhibited significant activity against the two cell lines. The in vitro antimicrobial screening showed that the thiazolines 2c, 5b and 5d showed promising inhibition activity against Salmonella sp. Additionally, the inhibition activity of thiazolines 2e and 5b against Escherichia coli was comparable to that of the reference compound gentamycin.

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