A bioresponsive diselenide-functionalized hydrogel with cascade catalytic activities for enhanced local starvation- and hypoxia-activated melanoma therapy

Ding, Xiaoran; Zang, Mingsong; Zhang, Yujie; Chen, Yongchen; Du, Jingjing; Yan, An; Gu, Jianyou; Li, Yuqi; Shu, Wei; Xu, Jing; Sun, Hongcheng; Yu, Shuangjiang

doi:10.1016/j.actbio.2023.06.017

Cited by 11 publications

(1 citation statement)

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“…The methods for preparing dextran hydrogels include crystallization, physical cross-linking, chemical cross-linking, radiation cross-linking copolymerization, and so on [127]. Bioresponsive diselenidefunctionalized dextran-based hydrogels with GPx-like catalytic activity was developed via Schiff base cross-linking for GSH consumption-enhanced local starvation-and hypoxiaactivated melanoma therapy [128]. The dextran-based hydrogel is pH-and dual redoxresponsive and could degrade sensitively and excite drug release with the increasing acid and H 2 O 2 , resulting in remarkably enhanced local anticancer efficacy.…”

Section: Dextran and Dextran-based Hydrogelmentioning

confidence: 99%

Natural Polymer-Based Hydrogels: From Polymer to Biomedical Applications

Zhao,

Zhou,

Zhang

et al. 2023

Pharmaceutics

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Hydrogels prepared from natural polymer have attracted extensive attention in biomedical fields such as drug delivery, wound healing, and regenerative medicine due to their good biocompatibility, degradability, and flexibility. This review outlines the commonly used natural polymer in hydrogel preparation, including cellulose, chitosan, collagen/gelatin, alginate, hyaluronic acid, starch, guar gum, agarose, and dextran. The polymeric structure and process/synthesis of natural polymers are illustrated, and natural polymer-based hydrogels including the hydrogel formation and properties are elaborated. Subsequently, the biomedical applications of hydrogels based on natural polymer in drug delivery, tissue regeneration, wound healing, and other biomedical fields are summarized. Finally, the future perspectives of natural polymers and hydrogels based on them are discussed. For natural polymers, novel technologies such as enzymatic and biological methods have been developed to improve their structural properties, and the development of new natural-based polymers or natural polymer derivatives with high performance is still very important and challenging. For natural polymer-based hydrogels, novel hydrogel materials, like double-network hydrogel, multifunctional composite hydrogels, and hydrogel microrobots have been designed to meet the advanced requirements in biomedical applications, and new strategies such as dual-cross-linking, microfluidic chip, micropatterning, and 3D/4D bioprinting have been explored to fabricate advanced hydrogel materials with designed properties for biomedical applications. Overall, natural polymeric hydrogels have attracted increasing interest in biomedical applications, and the development of novel natural polymer-based materials and new strategies/methods for hydrogel fabrication are highly desirable and still challenging.

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Section: Dextran and Dextran-based Hydrogelmentioning

confidence: 99%