A biphasic change of afterdischarge threshold during the kindling process

Emori, Kenji; Minabe, Yoshio; Kurachi, Masayoshi

doi:10.1016/0006-8993(90)90566-t

Cited by 6 publications

(1 citation statement)

References 14 publications

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“…The finding of kindling suppression effect by 5‐Hz stimulation in the present study is an interesting if considered that low‐frequency stimulation of 3 Hz was successfully used for kindling induction (e.g., Corcoran & Cain, 1980; Minabe et al., 1986; Emori et al., 1990). Of course, similar anticonvulsant effects were also observed with high‐frequency stimulations (Boon et al., 2007a,b; Van Roost et al., 2007).…”

Section: Discussionsupporting

confidence: 58%

The antiepileptogenic effect of electrical stimulation at different low frequencies is accompanied with change in adenosine receptors gene expression in rats

et al. 2009

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SUMMARYPurpose: Previous studies have shown that the anticonvulsant effects of low-frequency stimulation (LFS) can be affected by activation of adenosine receptors. In the present study, the effect of LFS at different frequencies on kindling rate and adenosine receptors gene expression was investigated. Methods: Animals were kindled by perforant path stimulation in a rapid kindling manner. LFS (0.5, 1, and 5 Hz) was applied after termination of each kindling stimulation. Seizure severity was measured according to behavioral and electrophysiologic parameters. At the end of the experiments, adenosine A 1 and A 2A receptor gene expression were measured. Results: The inhibitory effect of LFS on kindling acquisition was observed at all frequencies. In addition, the inhibitory action of LFS on enhancement of field excitatory postsynaptic potential slope and population spike amplitude during kindling acquisition was not affected by the LFS frequency. However, the effects of LFS on pairedpulse recordings were greater at frequency of 5 Hz. Application of LFS during kindling acquisition also prevented the kindling induced decrease in the A 1 receptor gene expression and attenuated the level of A 2A receptor gene expression in the dentate gyrus. These effects were also greater at the frequency of 5 Hz. Discussion: According to these data, it may be suggested that the antiepileptogenic effects of LFS, developed through inhibition of synaptic transmission in the dentate gyrus, is mediated somehow through preventing the decrease of A 1 receptor and through attenuating the A 2A receptor gene expression. These effects might be dependent on the frequency of LFS.

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