A bird’s-eye view of autophagy

Starokadomskyy, Petro; Dmytruk, Kostyantyn V.

doi:10.4161/auto.24544

Cited by 16 publications

(13 citation statements)

References 55 publications

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“…The term summarizes all self-destructing patterns in prokaryotic colonies including bacterial cannibalism, autolysis, programmed cell death, and other processes, in which a part of the colony is lysed and consumed by neighboring prokaryotic cells to recycle matter and energy. 1977…”

Section: Glossarymentioning

confidence: 99%

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Klionsky¹,

Abdelmohsen²,

Abe³

et al. 2016

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Section: Glossarymentioning

confidence: 99%

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Klionsky¹,

Abdelmohsen²,

Abe³

et al. 2016

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“…Towards the end of the 20th century, it was discovered that some forms of PCD (including apoptosis) exists not only in multicellular animals, but also in plants, lower eukaryotes, and yeast cells [71][72][73]. PCD in prokaryotes remained questionable for a long time; however, the facts supporting this have been accumulating over time and which demonstrate that microorganisms often behave as members of a multicellular community, adding support to the idea that the analogues of PCD exist in bacteria [72,[74][75][76].…”

Section: Allolysis As Weekdays Of the Bacterial "Multicellular" Lifementioning

confidence: 99%

Harnessing the Potential of Killers and Altruists within the Microbial Community: A Possible Alternative to Antibiotic Therapy?

et al. 2019

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In the context of a post-antibiotic era, the phenomenon of microbial allolysis, which is defined as the partial killing of bacterial population induced by other cells of the same species, may take on greater significance. This phenomenon was revealed in some bacterial species such as Streptococcus pneumoniae and Bacillus subtilis, and has been suspected to occur in some other species or genera, such as enterococci. The mechanisms of this phenomenon, as well as its role in the life of microbial populations still form part of ongoing research. Herein, we describe recent developments in allolysis in the context of its practical benefits as a form of cell death that may give rise to developing new strategies for manipulating the life and death of bacterial communities. We highlight how such findings may be viewed with importance and potential within the fields of medicine, biotechnology, and pharmacology.

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“…For example, UPS functions as the first line of defense under ER stress; however, autophagy targets ERAD‐resistant misfolded protein species for their elimination once ERAD gets compromised . In prokaryotes, where the presence of autophagy is yet to be established, proteasome is observed to be the only machinery that performs the task of degrading the proteins . Similarly, in eukaryotic cells, few cellular compartments lack autophagic machinery and proteasomal pathway has been sought to degrade proteins at those subcellular locations …”

Section: Evolved Sustenance Of Cells Under Stress Conditions: Multiplmentioning

confidence: 99%

“…420 In prokaryotes, where the presence of autophagy is yet to be established, proteasome is observed to be the only machinery that performs the task of degrading the proteins. 421,422 Similarly, in eukaryotic cells, few cellular compartments lack autophagic machinery and proteasomal pathway has been sought to degrade proteins at those subcellular locations. 423 In the cellular system, proteasomal pathway is very useful for regulating the half-lives of proteins, which are involved in different processes such as cell division, signaling, transcription, and metabolism.…”

Section: Functional Advantages Of Proteasome Pathway Compared To Othementioning

confidence: 99%

Proteasome‐mediated proteostasis: Novel medicinal and pharmacological strategies for diseases

Mishra

Upadhyay

Prajapati

et al. 2018

Medicinal Research Reviews

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Proteins actively participate in a wide range of cellular physiological functions. But aggregation of proteins results in cytotoxicity, and unwanted aggregation of misfolded proteins often causes many diseases. During abnormal protein aggregation events, cells try to cope against such deleterious consequences because of the remarkable functional attempts of two distinct proteolytic mechanisms. These tightly regulative and signaling mechanisms are autophagy pathway and ubiquitin proteasome system. Proteasome complex system holds the elimination capacity of intracellular aberrant protein aggregation. Despite the considerable progress that has been achieved, which elucidates wide function and diverse roles of proteasome system, still several crucial problems remain unanswered. For example, how the complex proteasomes assembly and their interactive pathways determine the precise sense of several proteotoxic insults, which can severely affect the cell survival and homeostasis? The specific degradation of various aberrant proteins that can disturb cellular homeostasis is achieved by proper proteasome functionality, which is yet another unclear and critical challenge. Therefore, a better understanding of the various cellular signaling mechanisms composing the proteasome machinery carries broad therapeutic implications linked with proteopathies. This article signifies the urgent need, which is now crucial for us to improve our understanding of the proteasome architecture, structure, and functions that span multiple level strategies from the molecular level to the cellular level. This systematic in-depth information of proteasome may be helpful in the near future to design a new molecular framework based on intrinsic and extrinsic cellular mechanisms that drive the assembly of proteasome to induce cellular survival against proteostasis imbalance and disease conditions.

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A bird’s-eye view of autophagy

Cited by 16 publications

References 55 publications

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Harnessing the Potential of Killers and Altruists within the Microbial Community: A Possible Alternative to Antibiotic Therapy?

Proteasome‐mediated proteostasis: Novel medicinal and pharmacological strategies for diseases

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