A bisphosphonate tweezers and clickable PEGylated PAMAM dendrons for the preparation of functional iron oxide nanoparticles displaying renal and hepatobiliary elimination

Ghobril, Cynthia; Popa, Gabriela; Parat, Audrey; Billotey, Claire; Taleb, Jacqueline; Bonazza, Pauline; Bégin‐Colin, Sylvie; Felder‐Flesch, Delphine

doi:10.1039/c3cc43161d

Cited by 35 publications

(35 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[75] Bis [76,77,78,79,80] or tri-phosphonates [81] as well as multi-catechols [82,83,84] have been recently reported and stability studies under various conditions have shown that NPs functionalized with such molecules (carboxylic acid 75 or catechol 83 ) are more stable than the NPs functionalized with only one anchoring group. Because of their excellent complexing properties, bisphosphonates were evaluated as coupling agents to iron oxide NPs.…”

Section: Anchoring Groupsmentioning

confidence: 99%

“…Because of their excellent complexing properties, bisphosphonates were evaluated as coupling agents to iron oxide NPs. 78 Portet et al [85] have studied stabilizing compounds having different anchoring groups such as sulfates, carboxylates, and showed that the functionalization using bisphosphonates provides stable colloidal suspensions of NPs over a long period (4 weeks). Torres et al have coupled a radioactive label to a bisphosphonate molecule and have functionalized iron oxide NPs.…”

Section: Anchoring Groupsmentioning

confidence: 99%

“…The use of dendrimers or dendrons in the biomedical field has been motivated by the many benefits that the arborescent structure of biomedical. In this way, dendrons were used to functionalize gold NPs, [123,124,125,126] quantum dots [127], polymeric NPs [128], carbon nanotubes, [129,130] surfaces [131] and in particular iron oxide NPs [61,62,72,78,83,91,93,128,132,133,134,135,136,137]. increase also increases the functionality of the NPs.…”

Section: Dendronized Iron Oxide Npsmentioning

confidence: 99%

“…32 Indeed the main reported application of dendronized NPs is their use as a contrast agent for MRI. 61,62,72,78,136,137 Iron oxide nanoparticles were coated with the dendron displayed in Figure 5. In vivo and in vitro MRI measurements showed that the contrast enhancement properties of the dendronized NPs were higher than those obtained with commercial polymer-coated NPs.…”

Section: Dendronized Iron Oxide Npsmentioning

confidence: 99%

See 3 more Smart Citations

Functionalization strategies and dendronization of iron oxide nanoparticles

Walter

Garofalo

Parat

et al. 2015

Nanotechnology Reviews

Self Cite

View full text Add to dashboard Cite

The articles presents main challenges in functionalization of iron oxide nanoparticles for biomedical applications. AbstractThe explosive growth of nanotechnology has brought challenging innovations in the synthesis of multifunctional nano-objects able to revolutionize the field of diagnosis and therapy in medicine. Furthermore one important input of today's nanotechnology in biology is that their design will also allow real progress to achieve temporal and spatial site local therapy and imaging. Such a breakthrough is made possible by the development of multifunctional biocompatible nanosystems resulting from cutting-edge researches based on pluridisciplinary approaches. Among challenges are the design of the organic coating and its grafting at the surface of NPs while preserving properties of both NPs and molecules. The molecules should ensure the colloidal stability of NPs in physiological media, their biocompatibility and biodistribution and may bear functions to couple bioactive groups. This paper aims at providing challenges in functionalization of iron oxide nanoparticles for biomedical applications.

show abstract

Section: Anchoring Groupsmentioning

confidence: 99%

Section: Anchoring Groupsmentioning

confidence: 99%

Section: Dendronized Iron Oxide Npsmentioning

confidence: 99%

Section: Dendronized Iron Oxide Npsmentioning

confidence: 99%

See 2 more Smart Citations

Functionalization strategies and dendronization of iron oxide nanoparticles

Walter

Garofalo

Parat

et al. 2015

Nanotechnology Reviews

Self Cite

View full text Add to dashboard Cite

show abstract

“…[3] However, MAG, used alone, is unstable in physiological media and needs a coated molecular layer to improve its biocompatibility, functionality, and stability. [4][5][6] One possible way to ameliorate these physicochemical factors is by loading iron oxide nanoparticles onto functionalized nanocarbons such as carbon nanotubes (CNTs) [7][8][9][10][11] and carbon nanohorns (CNHs). [12] Because of the exceptional combination of their mechanical, electronic, and thermal properties and chemical tolerance, nanocarbons are considered unique materials, with very promising future applications in a wide range of fields.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Carbon Nanohorn Complexes for Cancer Treatment

Chechetka

Pichon

Zhang

et al. 2014

Chemistry An Asian Journal

View full text Add to dashboard Cite

Multifunctional carbon nanohorn (CNH) complexes were synthesized using oxidized CNH, magnetite (MAG) nanoparticles, and polyethyleneimine (PEI). The ferromagnetic MAG nanoparticles were loaded onto CNH (MAG-CNH) using iron(II) acetate and subsequent heat treatment. Chemical functionalization of the MAG-CNH complexes with PEI improved their water-dispersibility and allowed further conjugation with a fluorophore. The application of an external magnetic field significantly intensified the targeted vectorization of CNH complexes into human cervical cancer (HeLa) cells. Following cell uptake, laser irradiation of the cells showed a significant enhancement in the photothermal effects of CNHs leading to cell death. We have confirmed that the photothermal properties and ferromagnetic characteristics of CNH complexes show efficient cell elimination. The present study is an essential step toward the development of an innovative cancer therapy and a highly sensitive detection of cancer cells at the single-cell level.

show abstract

Effect of the Functionalization Process on the Colloidal, Magnetic Resonance Imaging, and Bioelimination Properties of Mono‐ or Bisphosphonate‐Anchored Dendronized Iron Oxide Nanoparticles

et al. 2017

Self Cite

View full text Add to dashboard Cite

The functionalization process of iron oxide nanoparticles (NPs) is a major step and has to ensure a small particle size distribution (below 100 nm) and to preserve good magnetic properties suitable for in vivo applications. Two functionalization processes are here compared to coat iron oxide NPs, synthesized by thermal decomposition, with dendron molecules bearing either a mono‐ or a bisphosphonate anchoring group. The two processes are direct ligand exchange and the simultaneous ligand exchange and phase transfer process. The latter process led to a larger size distribution than the former. The phosphonate group is confirmed to be a strong anchoring agent from X‐ray photoelectron spectroscopy (XPS) and IR characterizations whatever the grafting process and the number of phosphonate groups, it also confirms the preservation of the NPs’ magnetic properties. All dendronized NPs display good in vitro MRI properties and those obtained by direct exchange showed no cell internalization, an efficient in vivo MRI contrast enhancement, and elimination by both urinary and hepato‐biliary ways.

show abstract

A bisphosphonate tweezers and clickable PEGylated PAMAM dendrons for the preparation of functional iron oxide nanoparticles displaying renal and hepatobiliary elimination

Abstract: The functionalization of superparamagnetic iron oxide nanoparticles (SPION) with PEGylated PAMAM dendrons through a bisphosphonate tweezers yielded 15 and 30 nm dendritic nano-objects stable in physiological media and showing both renal and hepatobiliary elimination.

Cited by 35 publications

References 22 publications

Functionalization strategies and dendronization of iron oxide nanoparticles

Functionalization strategies and dendronization of iron oxide nanoparticles

Multifunctional Carbon Nanohorn Complexes for Cancer Treatment

Effect of the Functionalization Process on the Colloidal, Magnetic Resonance Imaging, and Bioelimination Properties of Mono‐ or Bisphosphonate‐Anchored Dendronized Iron Oxide Nanoparticles

Contact Info

Product

Resources

About