A blend hydrogel based on polyoxometalate for long-term and repeatedly localized antibacterial application study

Fang, Yan; Liu, Taiyu; Xing, Cuili; Chang, Jiangnan; Li, Mingxue

doi:10.1016/j.ijpharm.2020.119990

Cited by 23 publications

(16 citation statements)

References 46 publications

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“…The reduction in the volume of exudate demonstrated a possible anti-inflammatory activity of the hydrogels and that result could be directly linked to induced cellular edema. The 7.2% HDCC and HDSC can be used as dressings for the treatment of tissue injuries, such as pressure injuries ( Figure 6 B) [ 55 , 56 ].…”

Section: Resultsmentioning

confidence: 99%

Polyacrylamide Hydrogel Containing Calendula Extract as a Wound Healing Bandage: In Vivo Test

Ferreira

Bandeira

Gomes

et al. 2023

IJMS

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Hydrogel is a biomaterial widely used in several areas of industry due to its great biocompatibility and adaptability to biological tissues. In Brazil, the Calendula plant is approved by the Ministry of Health as a medicinal herb. It was chosen to be incorporated in the hydrogel formulation because of its anti-inflammatory, antiseptic and healing effects. This study synthesized polyacrylamide hydrogel containing calendula extract and evaluated its efficiency as a bandage for wound healing. The hydrogels were prepared using free radical polymerization and characterized by Scanning Electron Microscopy, swelling analysis and mechanical properties by texturometer. The morphology of the matrices showed large pores and foliaceous structure. In vivo testing, as well as the evaluation of acute dermal toxicity, was conducted using male Wistar rats. The tests indicated efficient collagen fiber production, improved skin repair and no signs of dermal toxicity. Thus, the hydrogel presents compatible properties for the controlled release of calendula extract used as a bandage to promote cicatrization.

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Section: Resultsmentioning

confidence: 99%

Polyacrylamide Hydrogel Containing Calendula Extract as a Wound Healing Bandage: In Vivo Test

Ferreira

Bandeira

Gomes

et al. 2023

IJMS

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“…14 In particular, POMs have demonstrated surprising biological advantages in the treatment of infections associated with bacteria, which exert antibacterial activity through penetration. 15,16 Several POMs, especially polyoxomolybdates, have recognizable antibacterial activity against both Gramnegative and Gram-positive bacteria, depending on their composition, morphology, and size. 17,18 Ammonium molybdate, a kind of polyoxometalate, can be regarded as a watersoluble metal oxide with an oxygen-rich surface, whose structure, composition, and charge properties can be adjusted.…”

Section: Introductionmentioning

confidence: 99%

Large Ultrathin Polyoxomolybdate-Decorated Boron Nitride Nanosheets with Enhanced Antibacterial Activity for Infection Control

Zheng

Guan

et al. 2023

ACS Appl. Nano Mater.

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To address the challenges in bacterial infection for killing germs without using antibiotics, the development of an efficient and safe antibacterial nanomaterial to control severe bacterial infection has become a critical issue. Herein, ionic liquid (IL)-promoted simultaneous exfoliation and conjugation of boron nitride nanosheets (BNNSs) with ammonium dimolybdate (ADM) are developed. Such an approach provides large ultrathin nanosheets with three to four layers and micron lateral dimensions and facilitates intercalation with a molybdenum (Mo) content of 6.25%. BNNS-IL-ADM provides nanoconfinement inducing capability for sustained release of Mo ions to decelerate the cumulative release rate by 30.45%. BNNS-IL-ADM imparts a superior antibacterial effect especially at a low concentration level of bioactive components, which improves the antibacterial efficiency by 92.00% against Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus in comparison with ADM. The enhanced antibacterial performance is strongly dependent on the synergistic effect between the BN nanocarrier and bioactive ADM, in which the bacterial cell adhesion induced by the inherent hydrophobic property of the BNNS and the nanochannels within BNNS-IL-ADM protecting the bioactive ingredient and achieving a sustained release play significant roles. BNNS-IL-ADM can serve as a safe and efficient antibacterial agent with very low cytotoxicity. Such features offer a feasible strategy for simultaneous exfoliation and functionalization of boron nitride nanosheets as a promising platform for the delivery of bioactive ingredients against bacterial infections.

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“…19,20 Recently, magnesium oxide, zinc oxide, polyoxometalates, and copper-containing nanoparticles have been incorporated into hydrogel matrices to fabricate antibacterial wound dressings. 21–25 Another traditional and effective strategy to kill bacteria is the direct use of antibiotics. A better way is to prepare antibiotic-loaded hydrogels, and antibiotics could be selectively released at desirable sites thus relieving their drug-resistant effect.…”

Section: Introductionmentioning

confidence: 99%

EGCG-crosslinked carboxymethyl chitosan-based hydrogels with inherent desired functions for full-thickness skin wound healing

Wei

Zhang

et al. 2022

J. Mater. Chem. B

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A blend hydrogel based on polyoxometalate for long-term and repeatedly localized antibacterial application study

Cited by 23 publications

References 46 publications

Polyacrylamide Hydrogel Containing Calendula Extract as a Wound Healing Bandage: In Vivo Test

Polyacrylamide Hydrogel Containing Calendula Extract as a Wound Healing Bandage: In Vivo Test

Large Ultrathin Polyoxomolybdate-Decorated Boron Nitride Nanosheets with Enhanced Antibacterial Activity for Infection Control

EGCG-crosslinked carboxymethyl chitosan-based hydrogels with inherent desired functions for full-thickness skin wound healing

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