A blinded randomized controlled trial evaluating the efficacy of chitosan gel on ostial stenosis following endoscopic sinus surgery

Abstract

CD gel produced significantly less stenosis of all neo-ostia following ESS and may reduce the necessity for revision surgery in patients with chronic rhinosinusitis.

Efficacy and Safety of 3 Nasal Packing Materials Used After Functional Endoscopic Sinus Surgery for Chronic Rhinosinusitis: A Comparative Study in China

“…Chitosan materials are capable of aggregation and adhesion to red blood cells and platelets. They also activate the coagulation pathway and accelerate the synthesis of fibrin adhesive [14]. Chitosan can induce the production of endothelin, causing vasoconstriction and final wound closure to stop bleeding [15].…”

Product comparison model in otolaryngology: Equivalency analysis of absorbable hemostatic agents after endoscopic sinus surgery

“…This study did not examine subjective patient rated symptoms. Most recent work on CD showed that CD safely controls the bleeding in brain tissue and that CD gel produces significantly less stenosis of neoostia following ESS . Similarly, MPH initially was studied in a rabbit ESS model, where it did not detrimentally affect sinus mucosa as compared to untreated controls .…”

Randomized controlled trial: hybrid technique using balloon dilation of the frontal sinus drainage pathway

“…However, the study has established the safety and feasibility of the device used in this manner with successful intraoperative dilation in all cases and a reduction in blood loss and possibly operating time. Other recent studies looking at frontal sinus ostial stenosis following ESS have used a 3‐month postoperative follow‐up period to assess early outcomes . However, to establish longer‐term patency rates, further studies are required.…”

“…We looked at a number of alternative techniques to accurately measure ostial size, including postoperative CT scanning, but we felt that the small associated risk of radiation exposure was not warranted. Other recently published studies have used similar techniques to measure frontal sinus ostia size . In this study the size of the ostium is a secondary outcome and we used the best method available to accurately measure the size.…”