A Blinded, Randomized, Placebo-Controlled Study to Investigate the Efficacy and Safety of Ferric Carboxymaltose in Iron-Deficient Patients with Fibromyalgia

Boomershine, Chad S.; Koch, Todd A.; Morris, David

doi:10.1007/s40744-017-0088-9

Cited by 25 publications

(31 citation statements)

References 21 publications

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“…In line with recent findings 17 , our results suggested that iron supplementation reduces the risk of FM. However, serum hemoglobin and iron levels were similar between patients with FM with or without IDA 5 , 12 .…”

Section: Discussionsupporting

confidence: 93%

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The risk of fibromyalgia in patients with iron deficiency anemia: a nationwide population-based cohort study

Yao

Chen

Leong

et al. 2021

Sci Rep

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Since iron is essential for neurotransmitter synthesis, decreased iron stores might lead to reduced production of biogenic amines which phenomenon was shown in Fibromyalgia (FM) patients. The aims are to investigate the association of iron deficiency anemia (IDA) and FM and to find the effects of different interventions. We conducted a study using the Taiwan National Health Insurance Research Database. The IDA cohort consisted of 13,381 patients with newly diagnosed IDA between 2000 and 2008. Each patient with IDA was frequency-matched with one people without IDA, by sex, age and index year. The Cox proportional hazards regression analysis was conducted to estimate the association between IDA and FM risk. The event was the occurrence of FM. The overall incidence density rate of FM in the IDA cohort was higher than in the non-IDA cohort with a multivariable Cox proportional hazards model measured adjusted hazard ratio [HR], 1.19; 95% confidence interval [CI], 1.13–1.25). When using non-IDA group as reference, we compared with different therapies for IDA. The adjusted HRs of FM were 1.38 (95% CI = 1.30–1.47), 1.10 (95% CI = 1.03–1.16), 1.18 (95% CI = 0.98–1.43) and 0.73 (95% CI = 0.58–0.90) for IDA patient without therapy, iron supplement alone, blood transfusion alone and both iron supplement and blood transfusion respectively. Our results suggest IDA is associated with an increased risk of FM. All patients should have iron supplementation both to correct anemia and replenish body stores.

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Section: Discussionsupporting

confidence: 93%

“…Our results suggest that the prevalence of FM is higher in the IDA population compared with those without IDA. Furthermore, we revealed that a decreased iron level is associated with an increased risk of FM, which could potentially be reversed by iron supplementation 8,12,17 .…”

Section: Discussionmentioning

confidence: 87%

The risk of fibromyalgia in patients with iron deficiency anemia: a nationwide population-based cohort study

Yao

Chen

Leong

et al. 2021

Sci Rep

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“…With regard to other minerals, some studies indicated a potential link between iron deficiency and FM [45][46][47]; however, only one study evaluated the effect of iron supplementation on FM symptoms, fatigue and iron status of 81 FM subjects, showing an overall improvement only in the treated group [35].…”

Section: Mineralsmentioning

confidence: 99%

Nutritional Interventions in the Management of Fibromyalgia Syndrome

et al. 2020

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Fibromyalgia (FM) is a multifactorial syndrome of unknown etiology, characterized by widespread chronic pain and various somatic and psychological manifestations. The management of FM requires a multidisciplinary approach combining both pharmacological and nonpharmacological strategies. Among nonpharmacological strategies, growing evidence suggests a potential beneficial role for nutrition. This review summarizes the possible relationship between FM and nutrition, exploring the available evidence on the effect of dietary supplements and dietary interventions in these patients. Analysis of the literature has shown that the role of dietary supplements remains controversial, although clinical trials with vitamin D, magnesium, iron and probiotics’ supplementation show promising results. With regard to dietary interventions, the administration of olive oil, the replacement diet with ancient grains, low-calorie diets, the low FODMAPs diet, the gluten-free diet, the monosodium glutamate and aspartame-free diet, vegetarian diets as well as the Mediterranean diet all appear to be effective in reducing the FM symptoms. These results may suggest that weight loss, together with the psychosomatic component of the disease, should be taken into account. Therefore, although dietary aspects appear to be a promising complementary approach to the treatment of FM, further research is needed to provide the most effective strategies for the management of FM.

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“…Iron deficiency leads to general body pain, weakness, and fatigue; therefore, it can easily be confused with FS. Iron treatment in FS patients with iron deficiency may reduce these symptoms [30]. Serotonin and norepinephrine are vital for emotional behavior.…”

Section: Discussionmentioning

confidence: 99%

Could ferritin, vitamin B₁₂, and vitamin D play a role in the etiopathogenesis of fibromyalgia syndrome?

Küçük

Baykara

Tuzcu

et al. 2021

Romanian Journal of Internal Medicine

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Introduction: Fibromyalgia syndrome (FS) comprises general body pain, sleep disturbances, and fatigue. Vitamin B12 (VB), Vitamin D (VD), and iron deficiencies lead to similar complaints. First, this study aimed to evaluate the VB, VD, and ferritin levels of patients with FS. Second, it aimed to investigate whether there was a relationship between these parameters and FS severity. Material and Methods: The study included 58 female patients with FS and 58 healthy females as a control group. The patients completed the Fibromyalgia Impact Questionnaire (FIQ), Visual Analog Scale (VAS), fatigue questionnaire, Pittsburgh sleep quality scale, and the Short Form-36 (SF-36). This study examined the VD, VB, and ferritin levels of the patient and control groups. Results: The VB (240.0 [110.0-394.0] vs 291.0 [210.0-609.0] pg/ml, p<0.001), VD (12.5 [3.0-45.0] vs 20.0 [5.0-54.0] ng/ml, p=0.013), and ferritin levels (21.2 [4.0-86.0] vs 32.0 [7.1-120.0], ng/ml, p=0.009) of the FS patients were determined to be significantly lower than those of the control group. A negative correlation was determined between the number of tender points and VB, VD, and ferritin levels. In the regression analysis, we found low ferritin levels (odds ratio [OR] 1.036, 95% confidence interval [CI] 1.015-1.058, p<0.001) and VB (OR 1.010, CI 1.002-1.018, p=0.010) to be an independent risk factor for FS. Conclusions: There may be a relationship between VB, VD, and ferritin levels and the number of tender points in patients with FS. Levels of iron and VB may play a vital role in FS etiopathogenesis. However, VD levels may not risk factor for FS etiopathogenesis.

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A Blinded, Randomized, Placebo-Controlled Study to Investigate the Efficacy and Safety of Ferric Carboxymaltose in Iron-Deficient Patients with Fibromyalgia

Cited by 25 publications

References 21 publications

The risk of fibromyalgia in patients with iron deficiency anemia: a nationwide population-based cohort study

The risk of fibromyalgia in patients with iron deficiency anemia: a nationwide population-based cohort study

Nutritional Interventions in the Management of Fibromyalgia Syndrome

Could ferritin, vitamin B₁₂, and vitamin D play a role in the etiopathogenesis of fibromyalgia syndrome?

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A Blinded, Randomized, Placebo-Controlled Study to Investigate the Efficacy and Safety of Ferric Carboxymaltose in Iron-Deficient Patients with Fibromyalgia

Cited by 25 publications

References 21 publications

The risk of fibromyalgia in patients with iron deficiency anemia: a nationwide population-based cohort study

The risk of fibromyalgia in patients with iron deficiency anemia: a nationwide population-based cohort study

Nutritional Interventions in the Management of Fibromyalgia Syndrome

Could ferritin, vitamin B12, and vitamin D play a role in the etiopathogenesis of fibromyalgia syndrome?

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Product

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Could ferritin, vitamin B₁₂, and vitamin D play a role in the etiopathogenesis of fibromyalgia syndrome?