2022
DOI: 10.1038/s41397-022-00285-5
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A blockchain-based framework to support pharmacogenetic data sharing

Abstract: The successful implementation of pharmacogenetics (PGx) into clinical practice requires patient genomic data to be shared between stakeholders in multiple settings. This creates a number of barriers to widespread adoption of PGx, including privacy concerns related to the storage and movement of identifiable genomic data. Informatic solutions that support secure and equitable data access for genomic data are therefore important to PGx. Here we propose a methodology that uses smart contracts implemented on a blo… Show more

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Cited by 9 publications
(8 citation statements)
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“…Therefore, while the establishment of a PGx testing program in the province of Quebec will be challenging, we believe it to be achievable. To address the cost of PGx testing, pre-emptive and panel-based PGx can be deployed to reduce the number of single-gene tests, thus improving cost-effectiveness ( ODonnell et al, 2012 ; Bielinski et al, 2014 ; Van Driest et al, 2014 ; Klein et al, 2017 ; Blagec et al, 2022 ; Hayashi et al, 2022 ; Morris et al, 2022 ; Huang et al, 2023 ; McDermott et al, 2023 ; Swen et al, 2023 ) and with the added benefit of timelessness ( ODonnell et al, 2012 ; Johnson et al, 2013 ; Bielinski et al, 2014 ; Hoffman et al, 2014 ; Rasmussen-Torvik et al, 2014 ; Van Driest et al, 2014 ; Rosenman et al, 2017 ; Van Der Wouden et al, 2017 ; Chumnumwat et al, 2019 ; Duarte et al, 2021 ; Albalwy et al, 2022 ; Hayashi et al, 2022 ; Morris et al, 2022 ; Huang et al, 2023 ; Kabbani et al, 2023 ; McDermott et al, 2023 ; Oni-Orisan et al, 2023 ). Technologies such as NGS available in Quebec at institutions such as Genome Quebec ( Sequencing, 2023 ) can further decrease the cost of panel-based PGx testing to potentially a couple of USD ( Huang et al, 2023 ).…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…Therefore, while the establishment of a PGx testing program in the province of Quebec will be challenging, we believe it to be achievable. To address the cost of PGx testing, pre-emptive and panel-based PGx can be deployed to reduce the number of single-gene tests, thus improving cost-effectiveness ( ODonnell et al, 2012 ; Bielinski et al, 2014 ; Van Driest et al, 2014 ; Klein et al, 2017 ; Blagec et al, 2022 ; Hayashi et al, 2022 ; Morris et al, 2022 ; Huang et al, 2023 ; McDermott et al, 2023 ; Swen et al, 2023 ) and with the added benefit of timelessness ( ODonnell et al, 2012 ; Johnson et al, 2013 ; Bielinski et al, 2014 ; Hoffman et al, 2014 ; Rasmussen-Torvik et al, 2014 ; Van Driest et al, 2014 ; Rosenman et al, 2017 ; Van Der Wouden et al, 2017 ; Chumnumwat et al, 2019 ; Duarte et al, 2021 ; Albalwy et al, 2022 ; Hayashi et al, 2022 ; Morris et al, 2022 ; Huang et al, 2023 ; Kabbani et al, 2023 ; McDermott et al, 2023 ; Oni-Orisan et al, 2023 ). Technologies such as NGS available in Quebec at institutions such as Genome Quebec ( Sequencing, 2023 ) can further decrease the cost of panel-based PGx testing to potentially a couple of USD ( Huang et al, 2023 ).…”
Section: Discussionmentioning
confidence: 99%
“…This law needs to be made aware as it prevents, as seen in our American counterpart, social discrimination using genetic information by individuals or organizations such as insurance companies ( De Denus et al, 2013 ; Branch, 2017 ; Hayashi et al, 2022 ; Oni-Orisan et al, 2023 ). Continuing with ethical considerations, to guarantee a secure, interoperable and accessible centralized database and digital ecosystem ( Albalwy et al, 2022 ), a multitude of experts and committees are needed. Well-established Quebec organizations such as “ Plateforme de recherche, de valorisation, d’analyse et de liaison en informatique de la santé ” (PREVALIS), a platform developed by the Université de Sherbrooke (Quebec, Canada), provide services to develop such informatics tools as it is comprised of experts in the domains of informatics, artificial intelligence, health, pedagogy and ethics ( PREVALIS, 2023 ).…”
Section: Previously Raised Challenges and Efficient Solutionsmentioning
confidence: 99%
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“… Sajja et al (2021) discussed that blockchain-based agricultural and sector information allows clients to have faith in their data security while enabling global employment and heterogeneity. The data is related to the pharmacokinetics needed to collect the patient’s data and the worry about managing the privacy of the data, which is identifiable of the data that exposes the implementation of the blockchain-based data can be managed to the data that is accessed for the adoption of the system to produce the informatics solution and the stakeholders to produce the privacy worry and the storage movement that enables the genomic and the contracts which are proposed by Albalwy et al (2022) . Moreover, Alssaheli et al (2022) research distributes the nonprogrammable settings and incoming load balancing, enabling the existing load balancing and cloud facilities, which control traffic congestion.…”
Section: Literature Surveymentioning
confidence: 99%
“…As an emerging technology, blockchain applications are being explored in various industries, including healthcare [14][15][16][17], finance [18,19], real estate [20,21], agriculture [22,23], and education [24,25]. Blockchain implementation is ideal for communication networks, thanks to new improvements in blockchain technology such as decentralization, immutability, security, and transparency.…”
Section: Wireless Communications and Mobile Computingmentioning
confidence: 99%