2009
DOI: 10.1039/b910508e
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A blood sampling microsystem for pharmacokinetic applications: Design, fabrication, and initial results

Abstract: This paper describes a microsystem for automated blood sampling from laboratory mice used in pharmacokinetic studies. Intended to be mounted as a "backpack" on a mouse, it uses a microneedle, reservoir, and an actuator to instantaneously prick the animal for a time-point sample, eliminating the need for a tethered catheter with large dead volume. The blood is collected by capillary effect through a 31-33 gauge microneedle (250-210 microm OD) into a approximately 1 microL micromachined steel reservoir. The voic… Show more

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Cited by 35 publications
(19 citation statements)
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“…In contrast to drug delivery applications, hollow microneedles have also been developed to extract fluids from the body [142, 149, 174–175]. Glass and silicon hollow microneedles were used to obtain interstitial fluid, and stainless steel hollow microneedles were used for blood sampling.…”
Section: Fabrication Of Microneedlesmentioning
confidence: 99%
“…In contrast to drug delivery applications, hollow microneedles have also been developed to extract fluids from the body [142, 149, 174–175]. Glass and silicon hollow microneedles were used to obtain interstitial fluid, and stainless steel hollow microneedles were used for blood sampling.…”
Section: Fabrication Of Microneedlesmentioning
confidence: 99%
“…Novel methods of noninvasive sampling are ideal for pediatric applications and should be incorporated into ongoing collections and studies. For example, microfluidics technology may allow for repeated and accurate sampling of even our smallest patients in the neonatal intensive care unit [45–47]. Combining these collection methods with high-sensitivity analyses, such as high performance liquid chromatography, already shown to enable determination of concentrations of multiple drugs from a single dried blood spot card [48], creates a feasible way to perform suitably large pharmacogenetic studies in the pediatric population.…”
Section: Solution 2: Alternative Approaches To Sample Collection and Anmentioning
confidence: 99%
“…Earlier preclinical injection machines access larger targets, such as tumors [14], [15], or perform abdominal blood collection [16]. To access a target as small as the venous system of a small animal, a more maneuverable insertion robot with more degrees of freedom was developed to provide dexterous alignment and needle placement [17].…”
Section: Introductionmentioning
confidence: 99%