A Blue-Gray Macule on the Back: Answer

Aderibigbe, Oyinade; Groft-MacFarlane, Caroline; Chu, Emily Y.

doi:10.1097/dad.0000000000001267

Cited by 2 publications

(3 citation statements)

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“…4 Golden brown, "ochre-colored" elongated fibers, referred to as pseudoochronosis due to their histopathological resemblance to (alkaptonuric) ochronosis may occur. 8,9 Sulfur and selenium, present in this patient's biopsy, are often collocated with retained silver in tissue due to the formation of silver salts. 10 The relative anionic nature of basement membranes may provide a physicochemical explanation for the observed propensity of cationic metallic particles at these sites (Figs.…”

Section: Discussionmentioning

confidence: 94%

“…1 Histologically, argyria is characterized by particulate black-brown pigmented material within the reticular dermis around the elastic fibers, the basement membranes of the secretory coils of eccrine glands, and around neurovascular bundles. 4,8 Silver molecules can be found intracellularly in histiocytes and fibroblasts, but the majority are extracellular, which leads to prolonged dyspigmentation. 4 Golden brown, "ochre-colored" elongated fibers, referred to as pseudoochronosis due to their histopathological resemblance to (alkaptonuric) ochronosis may occur.…”

Section: Discussionmentioning

confidence: 99%

“…4 Golden brown, “ochre-colored” elongated fibers, referred to as pseudo-ochronosis due to their histopathological resemblance to (alkaptonuric) ochronosis may occur. 8,9…”

Section: Discussionmentioning

confidence: 99%

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Localized Cutaneous Argyria at the Site of a Prior Melanoma Excision Confirmed by Scanning Electron Microscopy With Energy Dispersive X-ray Analysis

McTighe,

Taylor,

Allbritton

et al. 2023

The American Journal of Dermatopathology

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Localized cutaneous argyria is a rare condition caused by the accumulation of silver particles in the skin, leading to blue–gray discoloration. Argyria may mimic melanoma and lead to misdiagnosis. We present a patient with a history of melanoma that developed a blue–gray nodule at a prior melanoma graft. The diagnosis was confirmed using scanning electron microscopy and energy dispersive x-ray analysis. These techniques differentiate argyria from melanoma and can be performed on formalin-fixed, paraffin-embedded, tissue sections. Health care providers should be alert that argyria may mimic recurrent melanoma in patients unaware of silver exposure.

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