A boronate-affinity magnetic molecularly imprinted polymer for luteolin recognition

Abstract

In this study, 3-carboxyphenylboronic acid (CP) functionalized amino-modified Fe3O4 (Fe3O4@NH2-CP, FNC) magnetic molecularly imprinted polymers (FNC@MIPs) were synthesized and applied to the rapid identification and selective separation of Luteolin (LTL)....

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“…A combination of these covalent-non-covalent synergistic forces could induce the formation of more imprinted cavities in polymers. Meanwhile, by comparing with other MIPs based on different monomers reported in previous literature (Table 3), this present study demonstrated excellent adsorption performance and recognition ability (Gao et al, 2016;Guo et al, 2021;Tong et al, 2021;Ding et al, 2023).…”

“…This strategy relies on the covalent binding interaction between boronic acid ligands and cis-diol-containing compounds at relatively higher pH values, with the complexes being released through dissociation under acidic conditions (Li et al, 2018;Bie and Chen, 2021;Li and Dong, 2021;. Fortunately, LTL contains the structure of cis-diols, and several researches have demonstrated that boronate affinity-based MIP could provide a new approach for the extraction and purification of LTL from natural products (Jia et al, 2018;Ding et al, 2023;Liu et al, 2023). Liu et al (2021) and has constructed two adsorbents, containing hydrophilic boronate affinity high internal phase emulsions MIP and graphene oxide-based MIP, which could capture and separate LTL from complex samples with high selectivity.…”

Magnetic materials as adsorbents for the pre‐concentration and separation of active ingredients from herbal medicine

“…Ding et al. [197] synthesized 3‐carboxyphenylboronic acid (CP)‐modified amino‐modified Fe 3 O 4 (Fe 3 O 4 @NH 2 ‐CP, FNC) magnetic MIPs (FNC@MIPs) and utilized them for the prompt recognition and selective isolation of Luteolin (LTL). The research team comprehensively assessed the performance of FNC@MIPs and observed that they exhibit uniform morphology, exceptional magnetic characteristics, rapid binding kinetics, high adsorption capacity, satisfactory selectivity, and sustained reusability.…”

Efficient separation of aristolochic acid I from Caulis aristolochiae manshuriensis (Guan-mu-tong) with copper mediated magnetic molecularly imprinted polymer

“…MIPs are a class of tailor-made materials and artificial antibodies. 22 They exhibit excellent recognition ability towards target molecules through the formatted special three-dimensional (3D) cavities by mimicking the antigen–antibody interactions. 23,24 Compared to other SPE materials, MIPs demonstrate high selectivity, good thermo-chemical stability, excellent mechanical strength, low cost, and easy preparation.…”