A BOSSS platform: using functionalized lipids and click chemistry for new discoveries in lipid research

Ford, David A.

doi:10.1016/j.jlr.2021.100025

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…The enhancement of LV function is most likely a consequence of these long-term effects and would therefore occur with a temporal delay. Recent chemoproteomic profiling studies of NO 2 -OA targets showing an impact on proteins responsible for protein and lipid trafficking and turnover support these speculations [48,49].…”

Section: Discussionmentioning

confidence: 94%

Nitro-Oleic Acid (NO2-OA) Improves Systolic Function in Dilated Cardiomyopathy by Attenuating Myocardial Fibrosis

Braumann

Schumacher

et al. 2021

IJMS

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Nitro-oleic acid (NO2-OA), a nitric oxide (NO)- and nitrite (NO2−)-derived electrophilic fatty acid metabolite, displays anti-inflammatory and anti-fibrotic signaling actions and therapeutic benefit in murine models of ischemia-reperfusion, atrial fibrillation, and pulmonary hypertension. Muscle LIM protein-deficient mice (Mlp−/−) develop dilated cardiomyopathy (DCM), characterized by impaired left ventricular function and increased ventricular fibrosis at the age of 8 weeks. This study investigated the effects of NO2-OA on cardiac function in Mlp−/− mice both in vivo and in vitro. Mlp−/− mice were treated with NO2-OA or vehicle for 4 weeks via subcutaneous osmotic minipumps. Wildtype (WT) littermates treated with vehicle served as controls. Mlp−/− mice exhibited enhanced TGFβ signalling, fibrosis and severely reduced left ventricular systolic function. NO2-OA treatment attenuated interstitial myocardial fibrosis and substantially improved left ventricular systolic function in Mlp−/− mice. In vitro studies of TGFβ-stimulated primary cardiac fibroblasts further revealed that the anti-fibrotic effects of NO2-OA rely on its capability to attenuate fibroblast to myofibroblast transdifferentiation by inhibiting phosphorylation of TGFβ downstream targets. In conclusion, we demonstrate a substantial therapeutic benefit of NO2-OA in a murine model of DCM, mediated by interfering with endogenously activated TGFβ signaling.

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Section: Discussionmentioning

confidence: 94%

Nitro-Oleic Acid (NO2-OA) Improves Systolic Function in Dilated Cardiomyopathy by Attenuating Myocardial Fibrosis

Braumann

Schumacher

et al. 2021

IJMS

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“…[48] Azide-alkyne "click" reactions have been applied to proteins, lipids, nucleic acids, and other biomolecules, revolutionizing the field of bioorthogonal chemistry. [49][50][51] However, Cu(I) is inherently toxic due to its ability to produce significant amounts of intracellular reactive oxygen species (ROS), which can damage the cell. [52]…”

Section: Coupling Reactionsmentioning

confidence: 99%

Modular Fabrication of Bioorthogonal Nanozymes for Biomedical Applications

et al. 2023

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The incorporation of transition metal catalysts (TMCs) into nanoscaffolds generates nanocatalysts that replicate key aspects of enzymatic behavior. The TMCs can access bioorthogonal chemistry unavailable to living systems. These bioorthogonal nanozymes can be employed as in situ “factories” for generating bioactive molecules where needed. The generation of effective bioorthogonal nanozymes requires co‐engineering of the TMC and the nanometric scaffold. This review presents an overview of recent advances in the field of bioorthogonal nanozymes, focusing on modular design aspects of both nanomaterial and catalyst and how they synergistically work together for in situ uncaging of imaging and therapeutic agents.This article is protected by copyright. All rights reserved

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A BOSSS platform: using functionalized lipids and click chemistry for new discoveries in lipid research

Cited by 2 publications

References 11 publications

Nitro-Oleic Acid (NO2-OA) Improves Systolic Function in Dilated Cardiomyopathy by Attenuating Myocardial Fibrosis

Nitro-Oleic Acid (NO2-OA) Improves Systolic Function in Dilated Cardiomyopathy by Attenuating Myocardial Fibrosis

Modular Fabrication of Bioorthogonal Nanozymes for Biomedical Applications

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