A "Boxer Glove" Contoured Laryngeal Amyloidosis

Lee, Eun Jung; Yang, Yun Su; Kim, Jong Seung; Hong, Ki Hwan

doi:10.3342/ceo.2012.5.4.240

Cited by 6 publications

(3 citation statements)

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“…Vocal fold injection for treating glottal insufficiency has gained popularity because of its noninvasiveness, its convenience, and the availability of variety injection materials 1,3,23-27. However, previously used graft materials were known to result in complications such as foreign body reactions or the formation of granulomas.…”

Section: Discussionmentioning

confidence: 99%

Autologous Platelet-Poor Plasma Gel for Injection Laryngoplasty

et al. 2013

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PurposeTo overcome the potential disadvantages of the use of foreign materials and autologous fat or collagen, we introduce here an autologous plasma gel for injection laryngoplasty. The purpose of this study was to present a new injection material, a plasma gel, and to discuss its clinical effectiveness.Materials and MethodsFrom 2 mL of blood, the platelet poor serum layer was collected and heated at 100℃ for 12 min to form a plasma gel. The plasma gel was then injected into a targeted site; the safety and efficacy thereof were evaluated in 30 rats. We also conducted a phase I/II clinical study of plasma gel injection laryngoplasty in 11 unilateral vocal fold paralysis patients.ResultsThe plasma gel was semi-solid and an easily injectable material. Of note, plasma gel maintains the same consistency for up to 1 year in a sealed bottle. However, exposure to room air causes the plasma gel to disappear within 1 month. In our animal study, the autologous plasma gel remained in situ for 6 months in animals with minimal inflammation. Clinical study showed that vocal cord palsy was well compensated for with the plasma gel in all patients at two months after injection with no significant complications. Jitter, shimmer, maximum, maximum phonation time (MPT) and mean voice handicap index (VHI) also improved significantly after plasma gel injection. However, because the injected plasma gel was gradually absorbed, 6 patients needed another injection, while the gel remained in place in 2 patients.ConclusionInjection laryngoplasty with autologous plasma gel may be a useful and safe treatment option for temporary vocal cord palsy.

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Section: Discussionmentioning

confidence: 99%

Autologous Platelet-Poor Plasma Gel for Injection Laryngoplasty

et al. 2013

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“…Sarcoidosis, metastatic tumors, polyps, malignant neoplasms, and salivary gland tumors are other possible differential diagnoses. 4 , 6 …”

Section: Discussionmentioning

confidence: 99%

Laryngeal amyloidosis presenting as false vocal fold bulging: clinical and therapeutic aspects

Neto

Alves

Gondra

2015

Brazilian Journal of Otorhinolaryngology

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“…Studies with long follow-up with amyloidosis of the larynx and trachea have reported that none of the patients developed systemic amyloidosis, B-cell lymphoma, or multiple myeloma. [5][6][7] Nevertheless, systemic workup is considered obligatory in every patient. Our patients had no lymphadenopathy, tender bones, and splenomegaly, which are suggesting the possibility of systemic amyloidosis.…”

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confidence: 99%