2024
DOI: 10.1101/2024.12.12.628169
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A Brain Reward Circuit Inhibited By Next-Generation Weight Loss Drugs

Elizabeth N. Godschall,
Taha Bugra Gungul,
Isabelle R. Sajonia
et al.

Abstract: Glucagon-like peptide-1 receptor agonists (GLP1RAs) effectively reduce body weight and improve metabolic outcomes, yet established peptide-based therapies require injections and complex manufacturing. Small-molecule GLP1RAs promise oral bioavailability and scalable manufacturing, but their selective binding to human versus rodent receptors has limited mechanistic studies. The neural circuits through which these emerging therapeutics modulate feeding behavior remain undefined, particularly in comparison to esta… Show more

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