A Brazilian experience of the self transglutaminase-based test for celiac disease case finding and diet monitoring

Abstract

AIM:To evaluate the effectiveness of a rapid and easy fingertip whole blood point-of-care test for celiac disease (CD) case finding and diet monitoring. METHODS:Three hundred individuals, 206 females (68.7%) and 94 males (31.3%), were submitted to a rapid and easy immunoglobulin-A-class fingertip whole blood point-of-care test in the doctor's office in order to make immediate clinical decisions: 13 healthy controls, 6 with CD suspicion, 46 treated celiacs, 84 relatives of the celiac patients, 69 patients with dyspepsia, 64 with irritable bowel syndrome (IBS), 8 with Crohn's disease and 9 with other causes of diarrhea. RESULTS:Upper gastrointestinal endoscopy with duodenal biopsies was performed in patients with CD suspicion and in individuals with positive test outcome: in 83.3% (5/6) of the patients with CD suspicion, in 100% of the patients that admitted gluten-free diet transgressions (6/6), in 3.8% of first-degree relatives (3/79) and in 2.9% of patients with dyspepsia (2/69). In all these individuals duodenal biopsies confirmed CD (Marsh's histological classification). The studied test showed good correlation with serologic antibodies, endoscopic and histological findings. CONCLUSION:The point-of-care test was as reliable as conventional serological tests in detecting CD cases and in CD diet monitoring.

Serological and Clinical Follow-Up of Relatives of Celiac Disease Patients from Southern Brazil

“…This is in agreement with the literature, which has demonstrated the predominance of CD in women, in a proportion of 2:1 to 2.9:1 [6,25,26]; besides, in this study, among the relatives with confirmed CD diagnosis (13/333), 7 were female. The lower gender ratio (1.16:1) observed may be due to the positive relatives who have refused biopsy.…”

Risk of Celiac Disease in the First- and Second-Degree Relatives of Patients With Celiac Disease: A Systematic Review and Meta-Analysis

“…One study was excluded based on exclusion criteria and 10 other studies were further excluded as they did not meet the quality assessment criteria to be included in our meta-analysis as described above ( 10,(20)(21)(22)(23)(24)(25)(26)(27)(28)(29). Finally, 54 articles were included in this meta-analysis ( 9,(11)(12)(13)(14) ( Figure 1 ).…”

“…Forty-one studies meeting the inclusion criteria were included in this part of meta-analysis ( 9,(11)(12)(13)(14)(74)(75)(76)(77)(78) ( Table 1 ). Forty-one studies meeting the inclusion criteria were included in this part of metaanalysis.…”

Dermatitis Herpetiformis, the Celiac Disease of the Skin!

“…The purpose includes compliance with GFD, reinforcing the importance of the diet, and to detect early signs of malabsorption and/or associated diseases. Monitoring the diet with serological tets (IgA EmA or IgA anti-tTG) is sensitive for major but not for minor transient dietary indiscretions (17) .…”