There are several areas of knowledge in which (pseudo-)random numbers are necessary, for example, in statistical–mathematical simulation or in cryptography and system security, among others. Depending on the area of application, it will be necessary that the sequences used meet certain requirements. In general, randomness and uniformity conditions are required in the generated sequences, which are checked with statistical tests, and conditions on sequence unpredictability if the application is in security. In the present work, a literature review on cryptographically secure pseudo-random number generators (CSPRNGs) is carried out, they are implemented, and a critical analysis of their statistical quality and computational efficiency is performed. For this purpose, different programming languages will be used, and the sequences obtained will be checked by means of the NIST Statistical Test Suite (NIST STS). In addition, a user’s guide will be provided to allow the selection of one generator over another according to its statistical properties and computational implementation characteristics.