A brief exposure to isoflurane (50 s) significantly impacts on plasma cytokine levels in endotoxemic rats

Hofstetter, Christian; Flondor, Michael; Boost, Kim Alexander; Koehler, Patricia; Bosmann, Markus; Pfeilschifter, Josef; Zwißler, Bernhard; Mühl, Heiko

doi:10.1016/j.intimp.2005.04.008

Cited by 41 publications

(48 citation statements)

References 6 publications

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“…In this context, extensive analyses have indicated that secretion of inflammatory mediators can be reduced through exposure to volatile anesthetics prior to ischemia and reperfusion (3,4). In addition, it was previously shown that, also in inflammatoryinduced situations of endotoxemia and acute lung injury, exposure to volatile anesthetics similarly attenuated the release of proinflammatory cytokines (5,6).…”

Section: Introductionmentioning

confidence: 99%

“…There is increasing evidence that these properties are mediated by inhibition of proinflammatory intracellular signal transduction pathways (17). Accordingly, it was demonstrated in animal models of LPS administration that the release of proinflammatory cytokines is markedly reduced by exposure to volatile anesthetics (5,18). Moreover, volatile anesthetics may modulate the immune response by decreasing neutrophil functions (19).…”

Section: Introductionmentioning

confidence: 99%

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Sevoflurane and isoflurane decrease TNF-α-induced gene expression in human monocytic THP-1 cells: Potential role of intracellular IκBα regulation

Boost

Leipold²,

Scheiermann³

et al. 2009

Int J Mol Med

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Abstract. The nuclear factor (NF)-κB/inhibitory (I)κB· pathway is one of the most important intracellular signal transduction pathways during inflammation which is induced by a variety of major early response cytokines. Recent studies suggest that volatile anesthetics interfere with inflammatory cytokine production through inhibition of intracellular signal transduction pathways. We, therefore, aimed to investigate the effects of the volatile anesthetics sevoflurane and isoflurane on NF-κB/IκB·-dependent intracellular signal transduction in human monocytic THP-1 cells induced by tumor necrosis factor-· (TNF-·) and production of interleukin-8 (IL-8) and downstream heme oxygenase-1 (HO-1). THP-1 cells, a human monocytic cell line, were used in an in vitro model which enables the exposure to volatile anesthetics. Using this model, THP-1 cells were subjected to sevoflurane or isoflurane exposure (1 MAC each) and were stimulated with TNF-· (50 or 100 ng/ml). Compared to untreated cells, expression of intracellular HO-1-protein and release of IL-8 into cell culture supernatants and corresponding mRNA expression were attenuated in THP-1 cells exposed to sevoflurane and isoflurane, respectively. Moreover, translocation of NF-κB and degradation of IκB· were markedly reduced by both anesthetics. Notably, under unstimulated conditions, exposure to sevoflurane induced a sustained upregulation of the IκB· content in THP-1 cells. We demonstrated inhibition of TNF-·-induced gene expression and release of IL-8 and HO-1 in human monocytic THP-1 cells exposed to both volatile anesthetics. This was associated with an upregulated intracellular IκB· content followed by decreased NF-κB translocation. This was more sustained during exposure to sevoflurane and may provide an additional intracellular mechanism for the anti-inflammatory effects associated with sevoflurane administration.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sevoflurane and isoflurane decrease TNF-α-induced gene expression in human monocytic THP-1 cells: Potential role of intracellular IκBα regulation

Boost

Leipold²,

Scheiermann³

et al. 2009

Int J Mol Med

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“…In opposition to these, there are other results of experimental studies showing the inhibition of LPS-induced iNOS expression in rat or murine macrophages caused by volatile anaesthetics (halothane, enflurane, isoflurane and desflurane) as well as the suppression of NO release by isoflurane or sevoflurane (31,33,34). It is believed that this mechanism of action of inhaled anaesthetics depends on the inhibition of intracellular calcium accumulation and decreased activity of the AP-1transcription factor.…”

Section: The Impact Of Inhaled Anaesthetics On the Function Of Macropmentioning

confidence: 99%

The Anti-Inflammatory and Immunosuppressive Properties of Inhaled Anaesthetics - Data from Experimental Studies and Clinical Implications

2017

ARC Journal of Anesthesiology

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“…However, depending on the experimental design, the same molecules may also have opposite effects (19). In humans, isoflurane may decrease phagocytic activity of human alveolar macrophages during surgery (21).…”

Section: Volatile Anestheticsmentioning

confidence: 99%

Immunological Modifications Induced from Products Used during the Perioperative Period

Cardinale

Mastrototaro

Cappiello

et al. 2011

Int J Immunopathol Pharmacol

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Anesthetics and other products used during the perioperative period may influence immune function not only merely by reducing the HPA-axis stress response but also by directly modulating innate and adaptive immune responses. Most of the literature on the immune effects of anesthetics has been derived from in vitro or animal studies, due to the number of confounding variables in “real life” surgical settings. These immunosuppressive effects might not normally have clinical consequences for an immune-competent patient, but may act as important modifiers in postoperative morbidity and mortality. Furthermore, some inhibitory effects on neutrophil functions may provide a therapeutically beneficial effect under specific surgical clinical conditions, such as ischemia-reperfusion injury.

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A brief exposure to isoflurane (50 s) significantly impacts on plasma cytokine levels in endotoxemic rats

Cited by 41 publications

References 6 publications

Sevoflurane and isoflurane decrease TNF-α-induced gene expression in human monocytic THP-1 cells: Potential role of intracellular IκBα regulation

Sevoflurane and isoflurane decrease TNF-α-induced gene expression in human monocytic THP-1 cells: Potential role of intracellular IκBα regulation

The Anti-Inflammatory and Immunosuppressive Properties of Inhaled Anaesthetics - Data from Experimental Studies and Clinical Implications

Immunological Modifications Induced from Products Used during the Perioperative Period

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