A brief history of corneal transplantation: From ancient to modern

Crawford, Alexandra X; Patel, Dipika V.; McGhee, Charles N J

doi:10.4103/0974-620x.122289

Cited by 44 publications

(20 citation statements)

References 30 publications

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“…It has been reported widely that the demand on healthy corneas exceeds the actual supply of donated corneas. 28 Likewise, there is also a lack of corneal supply in Jordan as the Director of Jordan Eye Bank has reported, with local corneal donation increasing to meet 65% of transplant needs in the Kingdom. 29 The low supply of donated corneas is mainly attributed to person’s attitude toward corneal donation, which is mainly affected by ethical, religious, and social issues and suggested to be influenced by lack of public awareness of eye donation and its benefits.…”

Section: Discussionmentioning

confidence: 99%

Public attitudes toward corneal donation in northern Jordan

Haddad

Khabour

Alzoubi

2018

OPTH

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PurposeThe aims of this study were to assess the knowledge and attitude toward corneal donation among Jordanian population and to report the reasons which may influence subject’s decision and attitude toward corneal donation.MethodsA self-designed questionnaire was developed. The participants were asked about reasons for both willingness and unwillingness to donate their corneas. These reasons were stated in the questionnaire and the participants had to express their agreement by one of five options: strongly disagree, disagree, neutral, agree, or strongly agree.ResultsA total of 500 participants (218 males and 282 females) completed the questionnaire. The average age (±SD) of the study participants was 32.8 (±11.7) years. About 67.2% of the subjects were willing to donate their corneas, whereas 32.8% were not willing to do so. The main motive for willingness was doing a good deed by helping others to see. On the other hand, fear of the body being treated badly and that other organ might be taken than the ones specified for donation were the main reasons for unwillingness to donate corneas. The age of participants, gender, and the monthly income did not significantly influence the willingness to donate (P>0.05). However, the level of education had a significant influence on people’s decision to donate their corneas.ConclusionMany Jordanians have positive attitude toward corneal donations. Ethical factors need to be addressed to promote for corneal donation. In addition, increasing the awareness of donation and its benefits may help increase the supply of corneal tissues.

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Section: Discussionmentioning

confidence: 99%

Public attitudes toward corneal donation in northern Jordan

Haddad

Khabour

Alzoubi

2018

OPTH

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“…Greek physician Galen (130-200 AD) proposed a form of superficial lamellar keratectomy to treat the opaque cornea. [ 1 4 ] In 1818, Franz Reisinger coined the term “Keratoplasty.” In 1886, Von Hippel performed a lamellar transplant where a full-thickness rabbit cornea was grafted on the lamellar bed of a human cornea. [ 1 4 ] It took a while after Eduard Zirm's first successful PK, to recognize the importance of within-species allograft.…”

Section: Historymentioning

confidence: 99%

“…[ 1 4 ] In 1818, Franz Reisinger coined the term “Keratoplasty.” In 1886, Von Hippel performed a lamellar transplant where a full-thickness rabbit cornea was grafted on the lamellar bed of a human cornea. [ 1 4 ] It took a while after Eduard Zirm's first successful PK, to recognize the importance of within-species allograft. Development in the field of immunology led to the recognition of the phenomenon of graft rejection.…”

Section: Historymentioning

confidence: 99%

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Lamellar keratoplasty techniques

Singh

Said

Dua

2018

Indian J Ophthalmol

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Lamellar keratoplasty (LK) has revolutionized corneal graft surgery in several ways. Deep anterior LK (DALK) has eliminated risk of failure due to endothelial rejection. Endothelial keratoplasty (EK) has almost eliminated induced astigmatism and the “weak” graft–host junction as seen with penetrating keratoplasty (PK) and also reduced the risk of endothelial rejection. LK provided new insights into posterior corneal anatomy that led to better understanding and performance of DALK and to the development of another EK procedure, namely pre-Descemet's EK (PDEK). Surgical procedures for LK were further refined based on the improved understanding and are able to deliver better surgical outcomes in terms of structural integrity and long-term patient satisfaction, reducing the need of further surgeries and minimizing patient discomfort. In most specialist centers, anterior lamellar techniques like DALK and EK techniques like Descemet's stripping EK (DSEK) and Descemet's membrane EK (DMEK) have replaced the full-thickness PK where possible. The introduction of microkeratome, femtosecond laser, and PDEK clamp have made LK techniques easier and more predictable and have led to the innovation of another LK procedure, namely Bowman membrane transplant (BMT). In this article, we discuss the evolution of different surgical techniques, their principles, main outcomes, and limitations. To date, experience with BMT is limited, but DALK has become the gold standard for anterior LK. The EK procedures too have undergone a rapid transition from DSEK to DMEK and PDEK emerging as a viable option. Ultrathin-DSEK may still have a role in modern EK.

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“…However, true surgical experiment came into reality in the 19 th century. A Successful human penetrating keratoplasty (PKP) was first performed by Eduard Zirm in 1905 for a patient with severe bilateral alkali burn (Crawford, Dipika, & Charles, 2013). The indications of corneal transplantation differ among various geographic areas.…”

Section: Introductionmentioning

confidence: 99%

Outcome of Penetrating Keratoplasty (PKP) and Redo PKP among Jordanian Population

Abu‐Ameerh¹,

Bdour²,

Al-Rawashdeh³

et al. 2019

RHS

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Background: The success of penetrating keratoplasty (PKP) is determined by the duration of graft survival, which is the time to graft failure. Our study aims to identify various indications of corneal graft among our Jordanian population, their success rate as well as spotting the light on cases of re-grafting. Methods: In this study, we analyzed data for patients who had PKP as well as re-do PKP in the period from January 2014 to June 2017. For each study eye, we identified pre-operative visual acuity as well as visual acuity at six months and one year. We also focused on the specific indication for PKP, the surgical procedure and graft clarity at one year post-op. On SPSS statistical analysis software, we used repeated measure ANOVA, Pearson correlations, and Fischer’s exact test to analyze our study’s variables.Results: We included a total of 230 patients in this study with a mean age of 34.22 (±19.32). They were 112 (48.7%) males and 118 (±51.3%) females. We found a significant difference in mean age and outcome (p< 0.001), as the mean age for patients with successful PKP was 31.55 (±16.55) compared to 44.1 (±25.1) for patients with failed PKP. the success rate for patients with KC as an indication was 96.7% compared to only 58.3% for other indications. We found that failure rate in redo surgeries was significantly higher than first time surgeries.Conclusion: Among the Jordanian population, we found that Keratoconus was the main indication for PKP in our population, where we also found that it was associated with the best prognosis.

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A brief history of corneal transplantation: From ancient to modern

Cited by 44 publications

References 30 publications

Public attitudes toward corneal donation in northern Jordan

Public attitudes toward corneal donation in northern Jordan

Lamellar keratoplasty techniques

Outcome of Penetrating Keratoplasty (PKP) and Redo PKP among Jordanian Population

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