A brief history of ‘new psychoactive substances’

King, Leslie A.; Kicman, Andrew T.

doi:10.1002/dta.319

Cited by 94 publications

(65 citation statements)

References 16 publications

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“…The structures varies, and have evolved into several different subclasses where indole and indazoles mostly comprise the base structure, even though some structures resembled traditional cannabinoids, while others contained other structural elements. 46 There are also several other synthetic cannabinoids that belongs to other compound groups. However, they all have (some) affinity for the CB1 cannabinoid receptor.…”

Section: The Evolution Of Synthetic Cannabinoidsmentioning

confidence: 99%

Synthesis and spectroscopic characterization of emerging synthetic cannabinoids and cathinones

Carlsson¹

2016

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The application of different analytical techniques is fundamental in forensic drug analysis. In the wake of the occurrence of large numbers of new psychoactive substances possessing similar chemical structures as already known ones, focus has been placed on applied criteria for their univocal identification. These criteria vary, obviously, depending on the applied technique and analytical approach. However, when two or more substances are proven to have similar analytical properties, these criteria no longer apply, which imply that complementary techniques have to be used in their differentiation.This work describes the synthesis of some structural analogues to synthetic cannabinoids and cathinones based on the evolving patterns in the illicit drug market. Six synthetic cannabinoids and six synthetic cathinones were synthesized, that, at the time for this study, were not as yet found in drug seizures. Further, a selection of their spectroscopic data is compared to those of already existing analogues; mainly isomers and homologues. The applied techniques were mass spectrometry (MS), Fourier transformed infrared (FTIR, gas phase) spectroscopy and nuclear magnetic resonance (NMR) spectroscopy. In total, 59 different compounds were analyzed with the selected techniques.

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Section: The Evolution Of Synthetic Cannabinoidsmentioning

confidence: 99%

Synthesis and spectroscopic characterization of emerging synthetic cannabinoids and cathinones

Carlsson¹

2016

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“…They produce similar effects. Although there is usually little or no information on their acute and particularly chronic harm, several intoxications and deaths have been reported [1,2].…”

Section: Introductionmentioning

confidence: 99%

Identification and characterization of a novel cathinone derivative 1-(2,3-dihydro-1H-inden-5-yl)-2-phenyl-2-(pyrrolidin-1-yl)-ethanone seized by customs in Jersey

et al. 2015

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A suspicious white powder labeled "idanyl-biphenyl-amninone", which was seized by customs at the "channel island" of Jersey, UK, was brought to our laboratory to identify and characterize its structure. For the elucidation process it required the use of several complementary analytical techniques, such as gas chromatography-mass spectrometry, liquid chromatography coupled to high-resolution mass spectrometry, nuclear magnetic resonance spectroscopy, and X-ray crystallography. The unknown compound was finally identified as 1-(2,3dihydro-1H-inden-5-yl)-2-phenyl-2-(pyrrolidin-1-yl)-ethanone, a novel cathinone derivative. To the best of our knowledge this compound has not been registered in the CAS or IUPAC database. However it has recently been marketed on the internet as "indapyrophenidone" and we therefore

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“…Full-scan and MS detection of anabolic steroid intact esters. Quite high levels (300-800 g/kg) of steroid esters are (King & Kicman, 2011).…”

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confidence: 99%

Application of mass spectrometry to hair analysis for forensic toxicological investigations

Vincenti

Salomone²,

Gerace³

et al. 2012

Mass Spectrometry Reviews

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The increasing role of hair analysis in forensic toxicological investigations principally owes to recent improvements of mass spectrometric instrumentation. Research achievements during the last six years in this distinctive application area of analytical toxicology are reviewed. The earlier state of the art of hair analysis was comprehensively covered by a dedicated book (Kintz, 2007a), that represents key reference of the present overview. Whereas the traditional organization of analytical methods in forensic toxicology divided target substances into quite homogeneous groups of drugs, with similar structures and chemical properties, the current approach often takes advantage of the rapid expansion of multiclass and multiresidue analytical procedures; the latter is made possible by the fast operation and extreme sensitivity of modern mass spectrometers. This change in the strategy of toxicological analysis is reflected in the presentation of the recent literature material, which is mostly based on a fit-for-purpose logic. Thus, general screening of unknown substances is applied in diverse forensic contexts than drugs of abuse testing, and different instrumentation (triple quadrupoles, time-of-flight analyzers, linear and orbital traps) is utilized to optimally cope with the scope. Other key issues of modern toxicology, such as cost reduction and high sample throughput, are discussed with reference to procedural and instrumental alternatives.

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A brief history of ‘new psychoactive substances’

Cited by 94 publications

References 16 publications

Synthesis and spectroscopic characterization of emerging synthetic cannabinoids and cathinones

Synthesis and spectroscopic characterization of emerging synthetic cannabinoids and cathinones

Identification and characterization of a novel cathinone derivative 1-(2,3-dihydro-1H-inden-5-yl)-2-phenyl-2-(pyrrolidin-1-yl)-ethanone seized by customs in Jersey

Application of mass spectrometry to hair analysis for forensic toxicological investigations

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