A Brief Journey of Tocotrienols as Anticancer Agents

Abstract

The journey of tocotrienol is started when the Vitamin E was first discovered as the fertility factor. Later in the research studies vitamin E was found to be consisting of eight isomers which can be divided into two separate groups known as tocopherols and tocotrienols. The isomers share similarity in structure but differ at much levels based upon their functional or biological properties. Initially tocopherols were investigated much due to their powerful antioxidant properties. However, the other four isomers of tocotrienols were found to be consisting of anticancer properties at varying degree in vitro and in vivo. The mechanisms mediated by tocotrienols such as NFkB pathway, apoptosis, and effect on DNA polymerases are totally different to those of tocopherols.

Fracionamento de extratos de subprodutos industriais de maracujá-azedo (Passiflora edulis Sims.) utilizando CO2 supercrítico e líquidos pressurizados

“…Extratos lipídicos vegetais foram reportados como principais fontes de tocóis, com destaque para castanhas e sementes oleaginosas. Os exemplos mais comuns são óleo de palma, azeite de oliva, óleo de semente de uva e de semente de girassol(KABIR et al, 2017). Alguns estudos demonstraram que o óleo de semente de maracujá Os fitosteróis estão presentes em óleo de semente de girassol, óleo de milho, óleo de amendoim, óleo de soja, entre outros, e além do estigmasterol, também são comumente encontrados campesterol, Δ5 -avenasterol e Δ…”