A brief overview of antitumoral actions of bruceine D

Sin, Zi Wayne; Bhardwaj, Vipul; Pandey, Amit Kumar; Garg, Manoj

doi:10.37349/etat.2020.00013

Cited by 8 publications

(8 citation statements)

References 149 publications

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“…5,6 The herb has been used for the treatment of a variety of conditions, including tumors, malaria, and inflammatory diseases. 7 The effectiveness may be due to the ability of BD to regulate important signaling pathways, such as PI3K/Akt/mTOR, JAK/ STAT, and JAG1/Notch. 7 Recently, BD was reported to effectively control the spread of plant-borne viruses, such as tobacco mosaic virus and potato virus Y.…”

Section: Introductionmentioning

confidence: 99%

“…7 The effectiveness may be due to the ability of BD to regulate important signaling pathways, such as PI3K/Akt/mTOR, JAK/ STAT, and JAG1/Notch. 7 Recently, BD was reported to effectively control the spread of plant-borne viruses, such as tobacco mosaic virus and potato virus Y. 8,9 BD is also effective in controlling pests such as Plutella xylostella L., Helicoverpa armigera Hubner, Spodoptera exigua Hiibner, and Dactylogyrus intermedius Monogenea, which exhibits outstanding antifeedant and growth inhibitory activity.…”

Section: Introductionmentioning

confidence: 99%

“…At present, the growth rate of biological pesticides has exceeded that of chemical pesticides, showing positive effects on reducing the use of chemical pesticides . Bruceine D (BD) is a natural compound isolated from the traditional Chinese herb Brucea javanica (L.) Merr., which originated in tropical areas of Africa and Asia. , The herb has been used for the treatment of a variety of conditions, including tumors, malaria, and inflammatory diseases . The effectiveness may be due to the ability of BD to regulate important signaling pathways, such as PI3K/Akt/mTOR, JAK/STAT, and JAG1/Notch …”

Section: Introductionmentioning

confidence: 99%

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Bruceine D Acts as a Potential Insecticide by Antagonizing 20E–EcR/USP Signal Transduction

Chen

Wang

et al. 2023

J. Agric. Food Chem.

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Bruceine D (BD) is an effective insecticidal compound found in the Chinese herb Brucea javanica (L.) Merr. BD inhibits the growth and metamorphosis of Plutella xylostella and Drosophila melanogaster; however, its target protein and the molecular mechanism of insecticidal activity remain unclear. In this study, proteins with high affinity for BD were screened using surface plasmon resonance and high-performance liquid chromatography coupled with matrix-assisted laser desorption/ionizationtime-of-flight mass spectrometry, revealing the ecdysone receptor (EcR) is the main target of BD. In vivo results showed that BD inhibited insect growth and metamorphosis through inhibition of the expression of 20E response genes. In vitro dual luciferase and enhanced green fluorescent protein (EGFP) fluorescence experiments indicated that BD suppressed the transcriptional activation activity of EcR by blocking the ecdysone response element (EcRE)-triggered transcriptional cascade, suggesting that BD inhibits the formation of the 20E−EcR−USP−EcRE complex. Moreover, molecular docking demonstrated that BD bound well to EcR. Elucidating the insecticidal mechanism of BD will be helpful in the development of green pesticides to control pests.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bruceine D Acts as a Potential Insecticide by Antagonizing 20E–EcR/USP Signal Transduction

Chen

Wang

et al. 2023

J. Agric. Food Chem.

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“…B. javanica oil is clinically used for adjuvant therapy, such as lung cancer, gastric cancer, esophageal cancer, and CRC (Liu et al., 2013; Lu et al., 2013; Wang et al., 2017; Xu et al., 2020). Like B. javanica oil, Bruceine D (BD) from B. javanica seeds has antitumor effects in diverse cancers (Sin et al., 2020). Researchers have revealed that BD exerts a tumor‐inhibiting activity by regulating some RNA molecules and signaling pathways.…”

Section: Introductionmentioning

confidence: 99%

Bruceine D restrains colorectal cancer tumorigenesis and autophagy by downregulating circ_0068464

Yang,

Li,

et al. 2023

Chem Biol Drug Des

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Bruceine D (BD) from Brucea javanica (L) exerts an antitumor effect in several human cancers. At present, it has not been reported whether BD inhibits the malignancy of colorectal cancer (CRC) cells. Therefore, investigating the role and regulatory mechanisms of BD in CRC is the main thrust of this study. Effect of BD on CRC cell viability, proliferation, apoptosis, invasion, and autophagy was determined by 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl‐2H‐tetrazolium bromide, 5‐ethynyl‐2′‐deoxyuridine, flow cytometry, transwell invasion, and western blotting assays. Expression changes of has_circ_0068464 (circ_0068464) were detected using real time quantitative polymerase chain reaction. The molecular mechanisms related to circ_0068464 were predicted through online prediction websites Starbase 2.0, circinteractome, and CircBank and validated using dual‐luciferase reporter and RNA pull‐down assays. The tumorigenic ability of BD and circ_0068464 on CRC was confirmed by xenograft experiments. The results showed that BD lessened CRC cell proliferation, invasion, autophagy, and prompted cell apoptosis. Circ_0068464 was overexpressed in CRC samples and cells. BD led to a significant reduction in circ_0068464 levels in cells of this carcinoma, but circ_0068464 overexpression partially rescued these effects urged by BD. Also, the combination of BD and circ_0068464 silencing decreased xenograft tumor growth compared to BD alone. Importantly, circ_0068464 could regulate ATG5 expression by functioning as a miR‐520h molecular sponge. In conclusion, BD might suppress CRC growth by inhibiting the circ_0068464/miR‐520h/ATG5 axis, providing a new perspective for the molecular pathogenesis of CRC and preliminarily indicating that BD may be a promising drug for CRC treatment.

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“…After evaluation between 102 compounds and BC cells under an acidic pH e , BD was suggested as the candidate with the most potential to treat BC against an experimental acidic condition with the highest IG value (IG value: 0.24) (Figure 3A and Table S5). BD is a major active quassinoid in Brucea javanica (L.) Merr., which has anti-cancer properties such as anti-proliferative and pro-apoptotic effects via c-Jun N-terminal kinase (JNK), mitogen-activated protein kinases (MAPK), phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of Rapamycin (mTOR), and canonical Wnt signaling pathways against many cancers including BC [33,34]. Our data showed that 10 probes defined as RUD and 24 probes defined as PDU in BC cells were potential therapeutic targets of BD.…”

Section: Discussionmentioning

confidence: 99%

In Silico Evaluation of Natural Compounds for an Acidic Extracellular Environment in Human Breast Cancer

Park¹,

Jeong

Seong

et al. 2021

Cells

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The survival rates for breast cancer (BC) have improved in recent years, but resistance, metastasis, and recurrence still remain major therapeutic challenges for BC. The acidic tumor microenvironment (TME) has attracted attention because of its association with tumorigenesis, metastasis, drug resistance, and immune surveillance. In this study, we evaluated natural compounds from traditional herbal medicine used to treat cancer that selectively target genes regulated by extracellular acidosis. We integrated four transcriptomic data including BC prognostic data from The Cancer Genome Atlas database, gene expression profiles of MCF-7 cells treated with 102 natural compounds, patterns of gene profiles by acidic condition, and single-cell RNA-sequencing from BC patient samples. Bruceine D (BD) was predicted as having the highest therapeutic potential, having an information gain (IG) score of 0.24, to regulate reprogrammed genes driven by acidosis affecting the survival of BC patients. BD showed the highest IG on EMT (IG score: 0.11) and invasion (IG score: 0.1) compared to the other phenotypes with the CancerSEA database. BD also demonstrated therapeutic potential by interfering with the tumor cell–TME interactions by reducing the amyloid beta precursor protein and CD44 expression. Therefore, BD is a potential candidate to target the acidic TME induced metastatic process in BC.

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A brief overview of antitumoral actions of bruceine D

Cited by 8 publications

References 149 publications

Bruceine D Acts as a Potential Insecticide by Antagonizing 20E–EcR/USP Signal Transduction

Bruceine D Acts as a Potential Insecticide by Antagonizing 20E–EcR/USP Signal Transduction

Bruceine D restrains colorectal cancer tumorigenesis and autophagy by downregulating circ_0068464

In Silico Evaluation of Natural Compounds for an Acidic Extracellular Environment in Human Breast Cancer

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