A Brief Overview of Recent Engineering Approaches for Intervertebral Disc Regeneration Using Adipose Derived Mesenchymal Stem Cell Administration

Kim, Sungjun; Kwon, Oh Joong; Lee, Jong-Hyeok; Kim, Jiyong; Kim, Tae Hyun; Kim, Kyobum

doi:10.1007/s12257-019-0346-5

Cited by 3 publications

(1 citation statement)

References 91 publications

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“…With the rapid development of tissue engineering, stem cell therapy is used to differentiate NP cells and achieve NP reconstructions in previous studies 10 , 11 . It is proved that stem cell therapy slowed down or reversed NP degeneration 12 – 14 .…”

Section: Introductionmentioning

confidence: 99%

Innovative design of minimal invasive biodegradable poly(glycerol-dodecanoate) nucleus pulposus scaffold with function regeneration

Wang

Jin

et al. 2023

Nat Commun

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Minimally invasive biodegradable implants with regeneration have been a frontier trend in clinic. Degeneration of nucleus pulposus (NP) is irreversible in most of spine diseases, and traditional spinal fusion or discectomy usually injure adjacent segments. Here, an innovative minimally invasive biodegradable NP scaffold with function regeneration inspired by cucumber tendril is developed using shape memory polymer poly(glycerol-dodecanoate) (PGD), whose mechanical property is controlled to the similar with human NP by adjusting synthetic parameters. The chemokine stromal cell-derived factor-1α (SDF-1α) is immobilized to the scaffold recruiting autologous stem cells from peripheral tissue, which has better ability of maintaining disc height, recruiting autologous stem cells, and inducing regeneration of NP in vivo compared to PGD without chemokine group and hydrogel groups significantly. It provides an innovative way to design minimally invasive implants with biodegradation and functional recovery, especially for irreversible tissue injury, including NP, cartilage and so on.

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