A Brief Survey of Taxus Alkaloids and Other Taxane Derivatives

Abstract

Alkaloids of the Taxaceae are briefly surveyed. Compounds containing the taxane nucleus are reviewed, including discussions of their isolation, nomenclature, and nmr, ms and X-ray analyses.

A New and Simply Available Class of Hydrosoluble Bioconjugates by Coupling Paclitaxel to Hyaluronic Acid through a 4‐Hydroxybutanoic Acid Derived Linker

“…± Since the 1980s, paclitaxel (1) [1], a well-known antitumor diterpenoid [2], has been adopted in the therapy of some cancer types [3]. Owing to its low solubility, it is administered as a castor oil (Cremophor )/EtOH solution.…”

Taxaceae A.Gray

“…In addition to the names taxine and taxol, names such as taxicin, taxacin, taxagifi ne, taxinin, taxusin, taxanine, taxicatin, taxinol, and taxininol have been applied to various isolations (Miller 1980;Khan and Parveen 1987). In addition to the names taxine and taxol, names such as taxicin, taxacin, taxagifi ne, taxinin, taxusin, taxanine, taxicatin, taxinol, and taxininol have been applied to various isolations (Miller 1980;Khan and Parveen 1987).…”

Comparative Pharmacognostic Studies on the Leaves of Abies spectabilis and Taxus wallichiana

“…Appendino et al, (1992) have identified two constituents taxine A (30%) and taxine B (2%) from an amorphous basic fraction known as taxine from the needles of T. wallichiana. Further, an impressive array of taxanes and other analogues, 10-deacetyl-baccatin III, 10-deacetyl-taxol, cephalomannine, 10-deacetyl-cephalomannine, 19-hydroxy-baccatin III were also identified and these are being used as intermediates for the semi-synthesis of Taxol (Appendino et al, 1993;Miller 1980;Mclaughlin et al, 1981). Presence of biflavonesamentoflavone, sciadopitysin, ginkgetin and scquoiaflavone were identified from the leaves of T. wallichiana.…”